| |  Online-Ressource |
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| Verfasst von: | Theiler-Schwetz, Verena [VerfasserIn]  |
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| | Trummer, Christian [VerfasserIn] |
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| | Grübler, Martin R. [VerfasserIn] |
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| | Keppel, Martin H. [VerfasserIn] |
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| | Zittermann, Armin [VerfasserIn] |
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| | Tomaschitz, Andreas [VerfasserIn] |
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| | Karras, Spyridon N. [VerfasserIn] |
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| | März, Winfried [VerfasserIn] |
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| | Pilz, Stefan [VerfasserIn] |
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| | Gängler, Stephanie [VerfasserIn] |
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| Titel: | Effects of vitamin D supplementation on 24-hour blood pressure in patients with low 25-hydroxyvitamin D levels |
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| Titelzusatz: | a randomized controlled trial |
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| Verf.angabe: | Verena Theiler-Schwetz, Christian Trummer, Martin R. Grübler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Spyridon N. Karras, Winfried März, Stefan Pilz and Stephanie Gängler |
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| E-Jahr: | 2022 |
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| Jahr: | 24 March 2022 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 18.05.2022 |
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| Titel Quelle: | Enthalten in: Nutrients |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 7, Artikel-ID 1360, Seite 1-12 |
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| ISSN Quelle: | 2072-6643 |
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| Abstract: | Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011-2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, p values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all p-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); p = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency. |
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| DOI: | doi:10.3390/nu14071360 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/nu14071360 |
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| | Volltext: https://www.mdpi.com/2072-6643/14/7/1360 |
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| | DOI: https://doi.org/10.3390/nu14071360 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | blood pressure |
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| | cardiovascular risk |
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| | cholecalciferol |
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| | vitamin D deficiency |
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| K10plus-PPN: | 1802468935 |
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| Verknüpfungen: | → Zeitschrift |
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Effects of vitamin D supplementation on 24-hour blood pressure in patients with low 25-hydroxyvitamin D levels / Theiler-Schwetz, Verena [VerfasserIn]; 24 March 2022 (Online-Ressource)
