Association of F2-isoprostane levels with Alzheimer’s disease in observational studies

• Verfasst von: Trares, Kira [VerfasserIn]
• Verfasst von: Chen, Li-Ju [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Titel: Association of F2-isoprostane levels with Alzheimer’s disease in observational studies
• Titelzusatz: a systematic review and meta-analysis
• Verf.angabe: Kira Trares, Li-Ju Chen, Ben Schöttker
• Jahr: 2022
• Umfang: 9 S.
• Fussnoten: Im Text ist "2" tiefgestellt ; Available online 24 December 2021 ; Gesehen am 20.05.2022
• Titel Quelle: Enthalten in: Ageing research reviews
• Ort Quelle: Oxford [u.a.] : Elsevier, 2002
• Jahr Quelle: 2022
• Band/Heft Quelle: 74(2022) vom: Feb., Artikel-ID 101552, Seite 1-9
• ISSN Quelle: 1872-9649
• DOI: doi:10.1016/j.arr.2021.101552
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 8-iso-prostaglandin F
• Sach-SW: Alzheimer’s Disease
• Sach-SW: F-isoprostanes
• Sach-SW: Observational studies
• Sach-SW: Oxidative stress
• Sach-SW: Systematic review
• K10plus-PPN: 1803972882

Abstract

Introduction - The association between F2-isoprostanes and Alzheimer’s disease (AD) has been controversially discussed in the literature since the 1990s. However, no systematic review has been performed so far. - Methods - A systematic review of observational studies on the associations of F2-isoprostanes and the specific biomarker 8-iso-prostaglandin F2α with AD were conducted. Random-effects model meta-analyses were performed. - Results - 29 studies were included in the systematic review, including four longitudinal studies. In an overall meta-analysis of the 25 cross-sectional studies, F2-isoprostane levels were statistically significantly associated with AD (Hedge’s g [95% confidence interval]: 1.00 [0.69-1.32]). When studies were grouped by biomarker and sample specimen, F2-isoprostane and 8-iso-prostaglandin F2α levels were statistically significantly elevated in tissue samples of the frontal lobe of AD patients. Moreover, F2-isoprostane levels in cerebrospinal fluid and 8-iso-prostaglandin F2α levels in blood samples of AD patients were significantly increased. Meta-analyses of the few longitudinal studies did not reach statistical significance. - Discussion - Increased concentrations of F2-isoprostanes were found in AD patients. However, due to the lack of adjustment in most cross-sectional case-control studies, results must be interpreted carefully. In addition, the causality of the association is uncertain because evidence from well-conducted longitudinal studies was conflicting, and further longitudinal studies are required to reinforce the results.