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Verfasst von:Ryschich, Eduard [VerfasserIn]   i
 Jesenofsky, Ralf [VerfasserIn]   i
 Ringel, Jörg [VerfasserIn]   i
 Harms, Walter [VerfasserIn]   i
 Fabian, Oliver V. [VerfasserIn]   i
 Saller, Robert [VerfasserIn]   i
 Schrewe, Michael [VerfasserIn]   i
 Engel, Alexander [VerfasserIn]   i
 Schmidt, Jan [VerfasserIn]   i
 Löhr, J.-Matthias [VerfasserIn]   i
Titel:Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells
Titelzusatz:Low-dose ifosfamide and local tumor irradiation
Verf.angabe:Eduard Ryschich, Ralf Jesnowski, Jörg Ringel, Walter Harms, Oliver V. Fabian, Robert Saller, Michael Schrewe, Alexander Engel, Jan Schmidt and Matthias Löhr
Jahr:2005
Umfang:5 S.
Fussnoten:First published: 30 November 2004 ; Gesehen am 23.05.2022
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2005
Band/Heft Quelle:113(2005), 4, Seite 649-653
ISSN Quelle:1097-0215
Abstract:Local therapy of pancreatic cancer with microencapsulated CYP2B1-producing cells and ifosfamide showed an effect both on the primary tumor and on distant metastatases. This possibly represents a consequence of the activation of immune response. Other studies have demonstrated that local tumor irradiation leads to the activation of the intratumoral lymphocyte infiltration. The aim of our study was to investigate the efficacy of the combined therapy with low-dose irradiation, ifosfamide and CYP2B1-producing cells. Syngenic pancreatic cancer was induced in 38 Lewis-rats by subcutaneous inoculation of 1 × 106 (DSL6A) tumor cells. Microencapsulated CYP2B1-producing cells were injected peritumorally 10--12 weeks after tumor implantation. Animals were randomized to the following groups: 1) control (NaCl, 1 ml i.p.), 2) ifosfamide (50 mg/kg, i.p., (3×/week), 3) local irradiation with 5 Gy and 4) ifosfamide plus irradiation. The tumor growth was monitored for 3 weeks. The tumor infiltration with CD4+, CD8+, NK-cells, microvessel density and proliferation rates were investigated by immunohistochemistry. Cytokine plasma level for TNF-α were measured by ELISA. Seven of 9 animals in the group of combined therapy showed an objective response to the therapy. The therapy with ifosfamide or radiation alone showed 5 and 3 responders, respectively. The mean tumor volume was significantly reduced after combined ifosfamide plus radiation therapy in the first week, whereas monotherapy with ifosfamide or radiation significantly decreased tumor growth earliest after 2 and 3 weeks, respectively. The high plasma level of TNF-α in the control group was significantly reduced after combined ifosfamide/irradiation treatment. The lymphocyte infiltration and tumor proliferation were not significantly different between the groups. Microvascular density was significantly increased after ifosfamide and ifosfamide plus irradiation therapy. The combination of ifosfamide/CYP2B1-producing cells and irradiation showed an earlier therapeutical effect on the growth of rat pancreatic cancer than the irradiation or ifosfamide alone. There was no evidence of late activation of lymphocyte infiltration and PCNA-positive tumor cells.
DOI:doi:10.1002/ijc.20627
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/ijc.20627
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.20627
 DOI: https://doi.org/10.1002/ijc.20627
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe: Ryschich, Eduard, 1967 - : Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells. - 2005
Sach-SW:cell therapy
 CYP2B1
 gene therapy
 ifosfamide
 pancreatic carcinoma
K10plus-PPN:1804114898
Verknüpfungen:→ Zeitschrift

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