| |  Online-Ressource |
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| Verfasst von: | Kubuschok, Boris [VerfasserIn]  |
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| | Xie, Xiaoxiun [VerfasserIn] |
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| | Jesenofsky, Ralf [VerfasserIn] |
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| | Preuss, Klaus-Dieter [VerfasserIn] |
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| | Romeike, Bernd F.M. [VerfasserIn] |
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| | Neumann, Frank [VerfasserIn] |
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| | Regitz, Evi [VerfasserIn] |
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| | Pistorius, Georg [VerfasserIn] |
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| | Schilling, Martin [VerfasserIn] |
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| | Scheunemann, Peter [VerfasserIn] |
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| | Izbicki, Jakob R. [VerfasserIn] |
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| | Löhr, J.-Matthias [VerfasserIn] |
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| | Pfreundschuh, Michael [VerfasserIn] |
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| Titel: | Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis |
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| Verf.angabe: | Boris Kubuschok, Xiaoxiun Xie, Ralf Jesnowski, Klaus-Dieter Preuss, Bernd F.M. Romeike, Frank Neumann, Evi Regitz, Georg Pistorius, Martin Schilling, Peter Scheunemann, Jakob R. Izbicki, J.-Matthias Löhr and Michael Pfreundschuh |
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| E-Jahr: | 2004 |
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| Jahr: | 22 January 2004 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 24.05.2022 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2004 |
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| Band/Heft Quelle: | 109(2004), 4, Seite 568-575 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines. While all CT genes were frequently expressed in cell lines derived from pancreatic cancer, no expression of MAGE-3, SSX-1, SSX-2, NY-ESO-1 and CT-7 was detected in fresh tumor biopsies, and MAGE-4 (1/52), SSX-4 (1/39) and CT-8 (2/41) were only rarely expressed. In contrast, HOM-TES-14/SCP-1 was expressed in 48% (29/61) and GAGE in 21% (13/61) of cases, respectively. One CT gene was expressed by 59% (75% in male, 46% in female patients; p = 0.05) and 2 or more CT genes by 15% of the samples. SCP-1 protein expression correlated well with mRNA expression. While SCP-1 and GAGE were absent in normal pancreas, they were found in 2/8 (SCP-1) and 1/8 (GAGE) samples of chronic pancreatitis, respectively, supporting the concept of chronic pancreatitis as a premalignant condition. SCP-1 and GAGE represent promising candidates for vaccine development in pancreatic carcinoma. Whether SCP-1 and GAGE expression identify cases of chronic pancreatitis with a high risk of malignant transformation remains to be shown. © 2004 Wiley-Liss, Inc. |
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| DOI: | doi:10.1002/ijc.20006 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/ijc.20006 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.20006 |
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| | DOI: https://doi.org/10.1002/ijc.20006 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer testis antigen |
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| | cancer vaccine |
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| | GAGE |
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| | MAGE |
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| | NY-ESO-1 |
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| | specific immunotherapy |
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| | SSX |
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| | tumor rejection antigen |
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| K10plus-PPN: | 1804293407 |
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| Verknüpfungen: | → Zeitschrift |
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Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis / Kubuschok, Boris [VerfasserIn]; 22 January 2004 (Online-Ressource)
