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Status: Bibliographieeintrag

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Verfasst von:Alldinger, Ingo [VerfasserIn]   i
 Dittert, Dag [VerfasserIn]   i
 Peiper, Matthias [VerfasserIn]   i
 Fusco, Alberto [VerfasserIn]   i
 Chiappetta, Gennaro [VerfasserIn]   i
 Staub, Eike [VerfasserIn]   i
 Löhr, J.-Matthias [VerfasserIn]   i
 Jesenofsky, Ralf [VerfasserIn]   i
 Baretton, Gustavo Bruno [VerfasserIn]   i
 Ockert, Detlef [VerfasserIn]   i
 Saeger, Hans-Detlev [VerfasserIn]   i
 Grützmann, Robert [VerfasserIn]   i
 Pilarsky, Christian [VerfasserIn]   i
Titel:Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer
Verf.angabe:Ingo Alldinger, Dag Dittert, Matthias Peiper, Alberto Fusco, Gennaro Chiappetta, Eike Staub, Matthias Löhr, Ralf Jesnowski, Gustavo Baretton, Detlef Ockert, Hans-Detlev Saeger, Robert Grützmann, Christian Pilarsky
Jahr:2005
Umfang:10 S.
Fussnoten:Elektronische Reproduktion der Druckausgabe ; Gesehen am 24.05.2022
Titel Quelle:Enthalten in: Pancreatology
Ort Quelle:Amsterdam : Elsevier, 2001
Jahr Quelle:2005
Band/Heft Quelle:5(2005), 4, Seite 370-379
ISSN Quelle:1424-3911
Abstract:Background: Pancreatic cancer is one of the leading causes of cancer-related death. Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines. Methods: We analyzed the gene expression of 5 established pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2 and HPAF II) and 5 primary isolates, 1 of them derived from benign pancreatic duct cells. Results: Out of 1,540 genes which were expressed in at least 3 experiments, we found 122 genes upregulated and 18 downregulated in tumor cell lines compared to benign cells with a fold change > 3. Several of the upregulated genes (like Prefoldin 5, ADAM9 and E-cadherin) have been associated with pancreatic cancer before. The other differentially regulated genes, however, play a so far unknown role in the course of human pancreatic carcinoma. By means of immunohistochemistry we could show that thymosin [β-10 (TMSB10), upregulated in tumor cell lines, is expressed in human pancreatic carcinoma, but not in non-neoplastic pancreatic tissue, suggesting a role for TMSB10 in the carcinogenesis of pancreatic carcinoma. Conclusion: Using gene expression profiling of pancreatic cell lines we were able to identify genes differentially expressed in pancreatic adenocarcinoma, which might contribute to pancreatic cancer development.
DOI:doi:10.1159/000086537
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000086537
 Volltext: https://www.sciencedirect.com/science/article/pii/S1424390305800109
 DOI: https://doi.org/10.1159/000086537
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cancer
 Cell line
 Immunohistochemistry
 Microarray
 Pancreas
 Primary isolates
 Thymosin
K10plus-PPN:180429490X
Verknüpfungen:→ Zeitschrift

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