| Online-Ressource |
Verfasst von: | Alldinger, Ingo [VerfasserIn]  |
| Dittert, Dag [VerfasserIn]  |
| Peiper, Matthias [VerfasserIn]  |
| Fusco, Alberto [VerfasserIn]  |
| Chiappetta, Gennaro [VerfasserIn]  |
| Staub, Eike [VerfasserIn]  |
| Löhr, J.-Matthias [VerfasserIn]  |
| Jesenofsky, Ralf [VerfasserIn]  |
| Baretton, Gustavo Bruno [VerfasserIn]  |
| Ockert, Detlef [VerfasserIn]  |
| Saeger, Hans-Detlev [VerfasserIn]  |
| Grützmann, Robert [VerfasserIn]  |
| Pilarsky, Christian [VerfasserIn]  |
Titel: | Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer |
Verf.angabe: | Ingo Alldinger, Dag Dittert, Matthias Peiper, Alberto Fusco, Gennaro Chiappetta, Eike Staub, Matthias Löhr, Ralf Jesnowski, Gustavo Baretton, Detlef Ockert, Hans-Detlev Saeger, Robert Grützmann, Christian Pilarsky |
Jahr: | 2005 |
Umfang: | 10 S. |
Fussnoten: | Elektronische Reproduktion der Druckausgabe ; Gesehen am 24.05.2022 |
Titel Quelle: | Enthalten in: Pancreatology |
Ort Quelle: | Amsterdam : Elsevier, 2001 |
Jahr Quelle: | 2005 |
Band/Heft Quelle: | 5(2005), 4, Seite 370-379 |
ISSN Quelle: | 1424-3911 |
Abstract: | Background: Pancreatic cancer is one of the leading causes of cancer-related death. Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines. Methods: We analyzed the gene expression of 5 established pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2 and HPAF II) and 5 primary isolates, 1 of them derived from benign pancreatic duct cells. Results: Out of 1,540 genes which were expressed in at least 3 experiments, we found 122 genes upregulated and 18 downregulated in tumor cell lines compared to benign cells with a fold change > 3. Several of the upregulated genes (like Prefoldin 5, ADAM9 and E-cadherin) have been associated with pancreatic cancer before. The other differentially regulated genes, however, play a so far unknown role in the course of human pancreatic carcinoma. By means of immunohistochemistry we could show that thymosin [β-10 (TMSB10), upregulated in tumor cell lines, is expressed in human pancreatic carcinoma, but not in non-neoplastic pancreatic tissue, suggesting a role for TMSB10 in the carcinogenesis of pancreatic carcinoma. Conclusion: Using gene expression profiling of pancreatic cell lines we were able to identify genes differentially expressed in pancreatic adenocarcinoma, which might contribute to pancreatic cancer development. |
DOI: | doi:10.1159/000086537 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000086537 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S1424390305800109 |
| DOI: https://doi.org/10.1159/000086537 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Cancer |
| Cell line |
| Immunohistochemistry |
| Microarray |
| Pancreas |
| Primary isolates |
| Thymosin |
K10plus-PPN: | 180429490X |
Verknüpfungen: | → Zeitschrift |
Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer / Alldinger, Ingo [VerfasserIn]; 2005 (Online-Ressource)