| |  Online-Ressource |
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| Verfasst von: | Alldinger, Ingo [VerfasserIn]  |
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| | Dittert, Dag [VerfasserIn] |
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| | Peiper, Matthias [VerfasserIn] |
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| | Fusco, Alberto [VerfasserIn] |
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| | Chiappetta, Gennaro [VerfasserIn] |
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| | Staub, Eike [VerfasserIn] |
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| | Löhr, J.-Matthias [VerfasserIn] |
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| | Jesenofsky, Ralf [VerfasserIn] |
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| | Baretton, Gustavo Bruno [VerfasserIn] |
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| | Ockert, Detlef [VerfasserIn] |
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| | Saeger, Hans-Detlev [VerfasserIn] |
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| | Grützmann, Robert [VerfasserIn] |
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| | Pilarsky, Christian [VerfasserIn] |
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| Titel: | Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer |
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| Verf.angabe: | Ingo Alldinger, Dag Dittert, Matthias Peiper, Alberto Fusco, Gennaro Chiappetta, Eike Staub, Matthias Löhr, Ralf Jesnowski, Gustavo Baretton, Detlef Ockert, Hans-Detlev Saeger, Robert Grützmann, Christian Pilarsky |
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| Jahr: | 2005 |
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| Umfang: | 10 S. |
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| Fussnoten: | Elektronische Reproduktion der Druckausgabe ; Gesehen am 24.05.2022 |
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| Titel Quelle: | Enthalten in: Pancreatology |
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| Ort Quelle: | Amsterdam : Elsevier, 2001 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 5(2005), 4, Seite 370-379 |
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| ISSN Quelle: | 1424-3911 |
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| Abstract: | Background: Pancreatic cancer is one of the leading causes of cancer-related death. Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines. Methods: We analyzed the gene expression of 5 established pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2 and HPAF II) and 5 primary isolates, 1 of them derived from benign pancreatic duct cells. Results: Out of 1,540 genes which were expressed in at least 3 experiments, we found 122 genes upregulated and 18 downregulated in tumor cell lines compared to benign cells with a fold change > 3. Several of the upregulated genes (like Prefoldin 5, ADAM9 and E-cadherin) have been associated with pancreatic cancer before. The other differentially regulated genes, however, play a so far unknown role in the course of human pancreatic carcinoma. By means of immunohistochemistry we could show that thymosin [β-10 (TMSB10), upregulated in tumor cell lines, is expressed in human pancreatic carcinoma, but not in non-neoplastic pancreatic tissue, suggesting a role for TMSB10 in the carcinogenesis of pancreatic carcinoma. Conclusion: Using gene expression profiling of pancreatic cell lines we were able to identify genes differentially expressed in pancreatic adenocarcinoma, which might contribute to pancreatic cancer development. |
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| DOI: | doi:10.1159/000086537 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000086537 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1424390305800109 |
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| | DOI: https://doi.org/10.1159/000086537 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer |
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| | Cell line |
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| | Immunohistochemistry |
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| | Microarray |
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| | Pancreas |
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| | Primary isolates |
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| | Thymosin |
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| K10plus-PPN: | 180429490X |
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| Verknüpfungen: | → Zeitschrift |
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Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer / Alldinger, Ingo [VerfasserIn]; 2005 (Online-Ressource)
