| |  Online-Ressource |
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| Verfasst von: | Göttmann, Uwe [VerfasserIn]  |
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| | Notheisen, Anneke [VerfasserIn] |
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| | Brinkkötter, Paul-Thomas [VerfasserIn] |
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| | Yard, Benito A. [VerfasserIn] |
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| | Waldherr, Rüdiger [VerfasserIn] |
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| | Schnülle, Peter [VerfasserIn] |
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| | Woude, Fokko J. van der [VerfasserIn] |
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| | Braun, Claude [VerfasserIn] |
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| Titel: | Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats |
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| Verf.angabe: | Uwe Gottmann, Anneke Notheisen, Paul T. Brinkkoetter, Benito A. Yard, Ruediger Waldherr, Peter Schnuelle, Fokko J. van der Woude, and Claude Braun |
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| Jahr: | 2005 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 25.05.2022 |
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| Titel Quelle: | Enthalten in: Transplantation |
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| Ort Quelle: | Hagerstown, Md. : Lippincott Williams & Wilkins, 1963 |
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| Jahr Quelle: | 2005 |
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| Band/Heft Quelle: | 79(2005), 10, Seite 1344-1350 |
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| ISSN Quelle: | 1534-6080 |
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| Abstract: | BACKGROUND: Retrospective transplant database analysis revealed that administration of catecholamines to organ donors reduces acute rejection episodes and improves graft survival after renal transplantation. In the present study, the authors investigated the influence of dopamine donor pretreatment before prolonged cold storage on short- and long-term graft outcome after allogeneic kidney transplantation. METHODS: Fisher donor rats were treated intravenously for 24 hr with dopamine or isotonic saline, Lewis rats treated with saline served as controls. Explanted kidneys were stored for 24 hr at 4 degrees C in University of Wisconsin solution and transplanted into Lewis rats. RESULTS: Dopamine pretreatment markedly reduced the infiltration of monocytes down to the level of isogeneic controls 5 days after allogeneic transplantation and hastened recovery of renal function in the first days after transplantation. After 24 weeks, serum creatinine and proteinuria were significantly lower in recipients of dopamine-treated grafts. Histologically, dopamine donor pretreatment significantly reduced the severity of chronic allograft nephropathy. Survival of animals that underwent transplantation was improved by dopamine pretreatment of donors (P=0.04). CONCLUSIONS: Pretreatment of organ donors with dopamine improves short- and long-term outcome after prolonged cold storage and subsequent allogeneic kidney transplantation in rats. The authors' experimental data demonstrate that donor treatment is a simple and effective approach for preventing long-term graft loss after kidney transplantation. |
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| DOI: | doi:10.1097/01.tp.0000159030.86574.6c |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/01.tp.0000159030.86574.6c |
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| | DOI: https://doi.org/10.1097/01.tp.0000159030.86574.6c |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Cryopreservation |
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| | Dopamine |
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| | Graft Survival |
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| | Kidney |
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| | Kidney Transplantation |
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| | Male |
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| | Organ Preservation |
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| | Premedication |
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| | Rats |
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| | Rats, Inbred F344 |
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| | Rats, Inbred Lew |
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| | Renal Insufficiency |
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| | Time Factors |
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| | Tissue and Organ Harvesting |
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| | Tissue Donors |
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| | Transplantation, Homologous |
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| K10plus-PPN: | 180437024X |
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| Verknüpfungen: | → Zeitschrift |
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Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats / Göttmann, Uwe [VerfasserIn]; 2005 (Online-Ressource)
