Gene expression in diabetic nephropathy

• Verfasst von: Rose, Daniela [VerfasserIn]
• Verfasst von: Woude, Fokko J. van der [VerfasserIn]
• Titel: Gene expression in diabetic nephropathy
• Verf.angabe: Daniela Hohenadel, and Fokko J. van der Woude
• Jahr: 2004
• Umfang: 8 S.
• Fussnoten: Gesehen am 27.05.2022
• Titel Quelle: Enthalten in: Current diabetes reports
• Ort Quelle: Heidelberg [u.a.] : Springer, 2001
• Jahr Quelle: 2004
• Band/Heft Quelle: 4(2004), 6, Seite 462-469
• ISSN Quelle: 1539-0829
• DOI: doi:10.1007/s11892-004-0057-x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Connective Tissue Growth Factor
• Sach-SW: Diabetic Nephropathy
• Sach-SW: Mesangial Cell
• Sach-SW: Suppression Subtractive Hybridization
• Sach-SW: Vascular Endothelial Growth Factor
• K10plus-PPN: 1804450480

Abstract

Diabetic nephropathy (DN) is a common complication of diabetes types 1 and 2. One of the hallmarks of DN is the development of mesangial expansion, which occurs through accumulation of extracellular matrix (ECM) components. Altered local gene expression of humoral factors (eg, transforming growth factor-â, connective tissue growth factor, and platelet-derived growth factor) can lead to increased production of ECM components (eg, fibronectin and collagen IV) or decreased degradation through matrix metal oproteinases (eg, MMP-1, MMP-2). In recent years, new techniques for examination of gene expression have been developed. Because of their large scale and high-throughput character, it is now possible to examine differential gene expression in a large number of samples. This paper provides an overview of techniques used and results obtained in studies of DN. Newly developed concepts of how altered gene expression may affect histomorphologic features or clinical symptoms are also discussed.