Fluorescence-guided minimally invasive parathyroidectomy

• Verfasst von: Proßt, Rüdiger Lothar [VerfasserIn]
• Verfasst von: Weiss, Johannes [VerfasserIn]
• Verfasst von: Hupp, Linus Christian [VerfasserIn]
• Verfasst von: Willeke, Frank [VerfasserIn]
• Verfasst von: Post, Stefan [VerfasserIn]
• Titel: Fluorescence-guided minimally invasive parathyroidectomy
• Titelzusatz: clinical experience with a novel intraoperative detection technique for parathyroid glands
• Verf.angabe: Ruediger L. Prosst, Johannes Weiss, Linus Hupp, Frank Willeke, Stefan Post
• E-Jahr: 2010
• Jahr: 29 May 2010
• Umfang: 6 S.
• Fussnoten: Gesehen am 30.05.2022
• Titel Quelle: Enthalten in: World journal of surgery
• Ort Quelle: [Hoboken, New Jersey : Wiley, 1977
• Jahr Quelle: 2010
• Band/Heft Quelle: 34(2010), 9, Seite 2217-2222
• ISSN Quelle: 1432-2323
• DOI: doi:10.1007/s00268-010-0621-2
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aminolevulinic Acid
• Sach-SW: Fluorescence Technique
• Sach-SW: Parathyroid Adenoma
• Sach-SW: Parathyroid Gland
• Sach-SW: Secondary Hyperparathyroidism
• K10plus-PPN: 1805186299

Abstract

Background: Detection of normal and pathologic parathyroid glands often is difficult due to their variability in number and location. We have implemented photosensitizer-induced fluorescence for the routine intraoperative identification of parathyroids for the surgical treatment of hyperparathyroidism. Methods: From 2004 to 2007, 25 patients suffering from primary and secondary hyperparathyroidism underwent minimally invasive videoscopic-assisted parathyroidectomy after oral photosensitization with aminolevulinic acid (ALA). Results: Fluorescence was sufficiently strong in 48% of patients to aid faster detection of the glands in situ. In an additional 44%, the fluorescence behavior supported the identification of the glands in situ and after excision, yielding a total of 92% of glands whose identity could be confirmed by the fluorescence technique.Conclusions: Fluorescence-guided minimally invasive parathyroidectomy is technically feasible and may support the surgeon in detecting and confirming the parathyroid glands. As the fluorescence method requires only moderate additional technical efforts and clinical expenditure, it is a valuable add-on component in parathyroid surgery to facilitate the operation.