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Status: Bibliographieeintrag

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Verfasst von:Beck, Grietje [VerfasserIn]   i
 Brinkkötter, Paul-Thomas [VerfasserIn]   i
 Dacho, Christine [VerfasserIn]   i
 Schulte, Jutta [VerfasserIn]   i
 Ackern, Klaus van [VerfasserIn]   i
 Woude, Fokko J. van der [VerfasserIn]   i
 Yard, Benito A. [VerfasserIn]   i
Titel:Clinical review
Titelzusatz:immunomodulatory effects of dopamine in general inflammation
Verf.angabe:Grietje Ch Beck, Paul Brinkkoetter, Christine Hanusch, Jutta Schulte, Klaus van Ackern, Fokko J van der Woude and Benito A Yard
E-Jahr:2004
Jahr:3 June 2004
Umfang:7 S.
Fussnoten:Gesehen am 31.05.2022
Titel Quelle:Enthalten in: Critical care
Ort Quelle:London : BioMed Central, 1997
Jahr Quelle:2004
Band/Heft Quelle:8(2004), 6, Seite 485-491
ISSN Quelle:1466-609X
Abstract:Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. Treatment of sepsis is based on surgical and/or antibiotic therapy, appropriate fluid management and application of vasoactive catecholamines. With respect to the latter, discussions on the vasopressor of choice are still ongoing. Over the past decade dopamine has been considered the 'first line' vasopressor and is frequently used to improve organ perfusion and blood pressure. However, there is a growing body of evidence that dopamine has deleterious side effects; therefore, its clinical relevance seems to be more and more questionable. Nevertheless, it has not been convincingly demonstrated that other catecholamines are superior to dopamine in this respect. Apart from its haemodynamic action, dopamine can modulate immune responses by influencing the cytokine network. This leads to inhibition of expression of adhesion molecules, inhibition of cytokine and chemokine production, inhibition of neutrophil chemotaxis and disturbed T-cell proliferation. In the present review we summarize our knowledge of the immunomodulatory effects of dopamine, with an emphasis on the mechanisms by which these effects are mediated.
DOI:doi:10.1186/cc2879
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://dx.doi.org/10.1186/cc2879
 Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065039/
 DOI: https://doi.org/10.1186/cc2879
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1805317725
Verknüpfungen:→ Zeitschrift

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