| |  Online-Ressource |
|---|
| Verfasst von: | Krzossok, Stefan [VerfasserIn]  |
|---|
| | Birck, Rainer [VerfasserIn] |
|---|
| | Köppel, Hannes [VerfasserIn] |
|---|
| | Schnülle, Peter [VerfasserIn] |
|---|
| | Waldherr, Rüdiger [VerfasserIn] |
|---|
| | Woude, Fokko J. van der [VerfasserIn] |
|---|
| | Braun, Claude [VerfasserIn] |
|---|
| Titel: | Treatment of proteinuria with low-molecular-weight heparin after renal transplantation |
|---|
| Verf.angabe: | Stefan Krzossok, Rainer Birck, Hannes Koeppel, Peter Schnülle, Rüdiger Waldherr, Fokko J. van der Woude, Claude Braun |
|---|
| Jahr: | 2004 |
|---|
| Umfang: | 5 S. |
|---|
| Fussnoten: | Gesehen am 31.05.2022 |
|---|
| Titel Quelle: | Enthalten in: Transplant international |
|---|
| Ort Quelle: | Lausanne : Frontiers Media, 1988 |
|---|
| Jahr Quelle: | 2004 |
|---|
| Band/Heft Quelle: | 17(2004), 8, Seite 468-472 |
|---|
| ISSN Quelle: | 1432-2277 |
|---|
| Abstract: | The development of nephrotic-range proteinuria after renal transplantation is an unfavourable prognostic factor for graft survival. In contrast to that in other nephropathies, the role of renin-angiotensin blockade in kidney transplantation is less well defined, and its anti-proteinuric effect is markedly reduced in the presence of segmental glomerulosclerosis. Here, we describe two patients who developed severe proteinuria after renal transplantation, despite effective blood pressure control with an ACE inhibitor. Histological changes were consistent with IgA-nephropathy and focal segmental glomerulosclerosis. Both patients were treated with low-molecular-weight heparin in addition to pre-existing ACE inhibition. This regimen led to a significant and long-lasting reduction of proteinuria. Our data suggest that low-molecular-weight heparin possesses strong renoprotective properties, thus confirming previous data from experimental nephropathies. This approach might represent a promising new strategy for treatment of proteinuria after kidney transplantation. |
|---|
| DOI: | doi:10.1007/s00147-004-0743-2 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/https://doi.org/10.1007/s00147-004-0743-2 |
|---|
| | DOI: https://doi.org/10.1007/s00147-004-0743-2 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Anticoagulants |
|---|
| | Heparin, Low-Molecular-Weight |
|---|
| | Humans |
|---|
| | Kidney Transplantation |
|---|
| | Male |
|---|
| | Middle Aged |
|---|
| | Postoperative Complications |
|---|
| | Proteinuria |
|---|
| | Time Factors |
|---|
| | Treatment Outcome |
|---|
| K10plus-PPN: | 1805329049 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Treatment of proteinuria with low-molecular-weight heparin after renal transplantation / Krzossok, Stefan [VerfasserIn]; 2004 (Online-Ressource)
