Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma

• Verfasst von: Sauer, Christian [VerfasserIn]
• Verfasst von: Römer, Alexandra [VerfasserIn]
• Verfasst von: Grobholz, Rainer [VerfasserIn]
• Titel: Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma
• Verf.angabe: Christian G. Sauer, Alexandra Roemer, and Rainer Grobholz (Department of Pathology, University Hospital Mannheim, Mannheim, Germany)
• E-Jahr: 2006
• Jahr: [15 February 2006]
• Jahr des Originals: 2005
• Umfang: 8 S.
• Illustrationen: Illustrationen
• Fussnoten: First published: 19 September 2005 ; Gesehen am 31.05.2022
• Titel Quelle: Enthalten in: The prostate
• Ort Quelle: New York, NY : Wiley-Liss, 1980
• Jahr Quelle: 2006
• Band/Heft Quelle: 66(2006), 3 vom: Feb., Seite 227-234
• ISSN Quelle: 1097-0045
• DOI: doi:10.1002/pros.20338
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: immunohistochemistry
• Sach-SW: laser capture microdissection
• Sach-SW: LNCaP
• Sach-SW: loss of heterozygosity
• Sach-SW: neuroendocrine differentiation
• Sach-SW: prostatic carcinoma
• K10plus-PPN: 1805360817

Abstract

BACKGROUND Neuroendocrine differentiated tumor cells can be found in the majority of prostatic adenocarcinomas. During antiandrogen or androgen-withdrawal therapy the neuroendocrine differentiation is often increased but its prognostic value is discussed controversially. The origin of neuroendocrine tumor cells is under discussion. While double staining experiments suggest a non-neoplastic pluripotent stem cell, in vitro studies demonstrate a transdifferentiation of exocrine tumor cells to a neuroendocrine phenotype. METHODS Neuroendocrine differentiated LNCaP cells and laser captured microdissected cells of eight radical prostatectomies were allelotyped using 11 microsatellite markers from seven different loci. RESULTS Identical allelic profiles were detected in untreated and neuroendocrine differentiated LNCaP cells for all markers confirming their clonality. Neuroendocrine and exocrine tumor cells from radical prostatectomies shared identical allelic profiles for all markers, suggesting a common origin for both cell populations. CONCLUSIONS Our results support the concept of transdifferentiation of exocrine tumor cells to a neuroendocrine tumor cell phenotype. © 2005 Wiley-Liss, Inc.