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Verfasst von:Sauer, Christian [VerfasserIn]   i
 Römer, Alexandra [VerfasserIn]   i
 Grobholz, Rainer [VerfasserIn]   i
Titel:Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma
Verf.angabe:Christian G. Sauer, Alexandra Roemer, and Rainer Grobholz (Department of Pathology, University Hospital Mannheim, Mannheim, Germany)
E-Jahr:2006
Jahr:[15 February 2006]
Jahr des Originals:2005
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:First published: 19 September 2005 ; Gesehen am 31.05.2022
Titel Quelle:Enthalten in: The prostate
Ort Quelle:New York, NY : Wiley-Liss, 1980
Jahr Quelle:2006
Band/Heft Quelle:66(2006), 3 vom: Feb., Seite 227-234
ISSN Quelle:1097-0045
Abstract:BACKGROUND Neuroendocrine differentiated tumor cells can be found in the majority of prostatic adenocarcinomas. During antiandrogen or androgen-withdrawal therapy the neuroendocrine differentiation is often increased but its prognostic value is discussed controversially. The origin of neuroendocrine tumor cells is under discussion. While double staining experiments suggest a non-neoplastic pluripotent stem cell, in vitro studies demonstrate a transdifferentiation of exocrine tumor cells to a neuroendocrine phenotype. METHODS Neuroendocrine differentiated LNCaP cells and laser captured microdissected cells of eight radical prostatectomies were allelotyped using 11 microsatellite markers from seven different loci. RESULTS Identical allelic profiles were detected in untreated and neuroendocrine differentiated LNCaP cells for all markers confirming their clonality. Neuroendocrine and exocrine tumor cells from radical prostatectomies shared identical allelic profiles for all markers, suggesting a common origin for both cell populations. CONCLUSIONS Our results support the concept of transdifferentiation of exocrine tumor cells to a neuroendocrine tumor cell phenotype. © 2005 Wiley-Liss, Inc.
DOI:doi:10.1002/pros.20338
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/pros.20338
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.20338
 DOI: https://doi.org/10.1002/pros.20338
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:immunohistochemistry
 laser capture microdissection
 LNCaP
 loss of heterozygosity
 neuroendocrine differentiation
 prostatic carcinoma
K10plus-PPN:1805360817
Verknüpfungen:→ Zeitschrift

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