Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients

• Verfasst von: Sauer, Christian [VerfasserIn]
• Verfasst von: Römer, Alexandra [VerfasserIn]
• Verfasst von: Späth, Monika [VerfasserIn]
• Verfasst von: Kaden, Jens [VerfasserIn]
• Verfasst von: Michel, Maurice Stephan [VerfasserIn]
• Verfasst von: Mayer, Doris [VerfasserIn]
• Verfasst von: Bleyl, Uwe [VerfasserIn]
• Verfasst von: Grobholz, Rainer [VerfasserIn]
• Titel: Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients
• Verf.angabe: Christian G. Sauer, Alexandra Kappeler, Monika Späth, Jens J. Kaden, Maurice S. Michel, Doris Mayer, Uwe Bleyl, Rainer Grobholz
• E-Jahr: 2004
• Jahr: 16 April 2004
• Umfang: 9 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 31.05.2022
• Titel Quelle: Enthalten in: Virchows Archiv
• Ort Quelle: Berlin : Springer, 1847
• Jahr Quelle: 2004
• Band/Heft Quelle: 444(2004), 6 vom: Apr., Seite 518-526
• ISSN Quelle: 1432-2307
• DOI: doi:10.1007/s00428-004-1016-2
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Gelatin zymography
• Sach-SW: Immunohistochemistry
• Sach-SW: Matrix metalloproteinases
• Sach-SW: Prostatic carcinoma
• Sach-SW: Western blot
• K10plus-PPN: 1805368060

Abstract

Prostate cancer is the most common cancer in men and second in the cancer-related frequency of mortality. Matrix metalloproteinases (MMPs) are involved in tumor invasion and metastasis in various malignancies. MMP-2 and MMP-9 are capable of digesting collagen type IV. Numerous studies have demonstrated an association between increased MMP-2 and -9 expression and tumor progression in various tumors. In this study, the expression and activities of MMP-2 and -9 were assessed in serum probes and tumor tissue from core needle biopsies and radical prostatectomies of 97 patients. MMP-2 and -9 serum expression was analyzed in a subgroup of 31 patients. MMP-9 serum expression was significantly increased in tumor patients and correlated with tumor grade. In contrast, the MMP-9 tissue expression and activity revealed no significant correlations to tumor stage or grade. The MMP-2 activity, however, showed a positive correlation for MMP-2 with tumor stage. Increased activity was predominantly detected in advanced tumor stages. Immunohistochemical analysis of MMP-2 expression demonstrated a positive association with tumor grade in prostatectomy specimens. The relative expression rates in biopsies matched in 65% with those of the prostatectomies. Detection of MMP-2 in core needle biopsies seems not to be a helpful marker for diagnostic purposes.