Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Böttcher, Sebastian [VerfasserIn]  |
| Ritgen, Matthias [VerfasserIn]  |
| Dreger, Peter [VerfasserIn]  |
Titel: | Allogeneic stem cell transplantation for chronic lymphocytic leukemia |
Titelzusatz: | Lessons to be learned from minimal residual disease studies |
Verf.angabe: | Sebastian Böttcher, Matthias Ritgen, Peter Dreger |
E-Jahr: | 2011 |
Jahr: | 26 January 2011 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 03.06.2022 |
Titel Quelle: | Enthalten in: Blood reviews |
Ort Quelle: | Burlington, Mass. : Harcourt, 1987 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 25(2011), 2, Seite 91-96 |
ISSN Quelle: | 1532-1681 |
Abstract: | Allogeneic stem cell transplantation (alloSCT) is a potentially curative treatment strategy for poor-risk chronic lymphocytic leukemia (CLL). The crucial anti-leukemic principle of alloSCT in CLL appears to be the graft-versus-leukemia effect (GVL). Evidence for GVL in CLL is particularly provided by studies analysing the kinetics of minimal residual disease (MRD). The purpose of this review is to summarize the methodologies of MRD assessment, its proven benefits and its further perspectives for optimizing the outcome of transplantation. Proven value of quantitative MRD monitoring by RQ-PCR or MRD-flow consists in using it as an indicator of long-term disease control and potential cure. As MRD kinetics correlates with GVL activity, its suitability for guiding GVL-inducing immunomodulation is currently under investigation. In conclusion, quantitative MRD monitoring seems to be mandatory to assure safe and effective immunotherapy in the context of alloSCT for CLL, which should, however, be best performed within clinical studies. |
DOI: | doi:10.1016/j.blre.2011.01.001 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.blre.2011.01.001 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0268960X11000026 |
| DOI: https://doi.org/10.1016/j.blre.2011.01.001 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Allogeneic stem cell transplantation |
| Chronic lymphocytic leukemia |
| Minimal residual disease |
K10plus-PPN: | 180589062X |
Verknüpfungen: | → Zeitschrift |
Allogeneic stem cell transplantation for chronic lymphocytic leukemia / Böttcher, Sebastian [VerfasserIn]; 26 January 2011 (Online-Ressource)
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