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Verfasst von:Weinschenk, Stefan [VerfasserIn]   i
 Weiss, Carsten [VerfasserIn]   i
 Benrath, Justus [VerfasserIn]   i
 Baehr, Volker von [VerfasserIn]   i
 Strowitzki, Thomas [VerfasserIn]   i
 Feißt, Manuel [VerfasserIn]   i
Titel:Anti-Inflammatory characteristics of local anesthetics
Titelzusatz:inhibition of TNF-α secretion of lipopolysaccharide-stimulated leucocytes in human blood samples
Verf.angabe:Stefan Weinschenk, Carsten Weiss, Justus Benrath, Volker von Baehr, Thomas Strowitzki and Manuel Feißt
E-Jahr:2022
Jahr:18 March 2022
Umfang:14 S.
Fussnoten:Gesehen am 04.06.2022
Titel Quelle:Enthalten in: International journal of molecular sciences
Ort Quelle:Basel : Molecular Diversity Preservation International, 2000
Jahr Quelle:2022
Band/Heft Quelle:23(2022), 6, Artikel-ID 3283, Seite 1-14
ISSN Quelle:1422-0067
 1661-6596
Abstract:Background. Local anesthetics (LAs) have potent anti-inflammatory properties. Inflammatory down-regulation is crucial in diseases with overactive immune reactions, such as acute respiratory distress syndrome (ARDS) and chronic inflammation. We investigated the influence of four LAs, procaine, lidocaine, mepivacaine, and bupivacaine, on the reduction of tumor necrosis factor-alpha (TNF-α) secretion in lipopolysaccharide (LPS)-activated human leucocytes. Methods. Blood samples of 28 individuals were stimulated with LPS. The reduction of TNF-α production by each of the four LAs added (0.5 mg/mL) was measured and correlated with biometric variables. A response was defined as reduction to <85% of initial levels. Results. All four LAs down-regulated the TNF-α secretion in 44-61%: Bupivacaine (44.4%), lidocaine (61.5%), mepivacaine (44.4%), and procaine (50% of the individuals, “responders”). The TNF-α secretion was reduced to 67.4, 68.0, 63.6, and 67.1% of the initial values in responders. The effects in both patients and healthy persons were the same. Interindividual responses to LAs were not correlated with the duration or type of complaints, basal TNF-α serum level, sex, BMI, or age of responders. Conclusions. Four clinically relevant LAs (amid-LA and ester-LA) attenuate the inflammatory response provoked by LPS. They are potential candidates for drug repositioning in treating overactive immune reactions and chronic inflammation.
DOI:doi:10.3390/ijms23063283
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/ijms23063283
 Volltext: https://www.mdpi.com/1422-0067/23/6/3283
 DOI: https://doi.org/10.3390/ijms23063283
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:clinical study
 cytokines
 local anesthetics
 LPS
 neural therapy
 tumor necrosis factor-alpha
K10plus-PPN:1806076136
Verknüpfungen:→ Zeitschrift

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