Anti-Inflammatory characteristics of local anesthetics

• Verfasst von: Weinschenk, Stefan [VerfasserIn]
• Verfasst von: Weiss, Carsten [VerfasserIn]
• Verfasst von: Benrath, Justus [VerfasserIn]
• Verfasst von: Baehr, Volker von [VerfasserIn]
• Verfasst von: Strowitzki, Thomas [VerfasserIn]
• Verfasst von: Feißt, Manuel [VerfasserIn]
• Titel: Anti-Inflammatory characteristics of local anesthetics
• Titelzusatz: inhibition of TNF-α secretion of lipopolysaccharide-stimulated leucocytes in human blood samples
• Verf.angabe: Stefan Weinschenk, Carsten Weiss, Justus Benrath, Volker von Baehr, Thomas Strowitzki and Manuel Feißt
• E-Jahr: 2022
• Jahr: 18 March 2022
• Umfang: 14 S.
• Fussnoten: Gesehen am 04.06.2022
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2022
• Band/Heft Quelle: 23(2022), 6, Artikel-ID 3283, Seite 1-14
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms23063283
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: clinical study
• Sach-SW: cytokines
• Sach-SW: local anesthetics
• Sach-SW: LPS
• Sach-SW: neural therapy
• Sach-SW: tumor necrosis factor-alpha
• K10plus-PPN: 1806076136

Abstract

Background. Local anesthetics (LAs) have potent anti-inflammatory properties. Inflammatory down-regulation is crucial in diseases with overactive immune reactions, such as acute respiratory distress syndrome (ARDS) and chronic inflammation. We investigated the influence of four LAs, procaine, lidocaine, mepivacaine, and bupivacaine, on the reduction of tumor necrosis factor-alpha (TNF-α) secretion in lipopolysaccharide (LPS)-activated human leucocytes. Methods. Blood samples of 28 individuals were stimulated with LPS. The reduction of TNF-α production by each of the four LAs added (0.5 mg/mL) was measured and correlated with biometric variables. A response was defined as reduction to <85% of initial levels. Results. All four LAs down-regulated the TNF-α secretion in 44-61%: Bupivacaine (44.4%), lidocaine (61.5%), mepivacaine (44.4%), and procaine (50% of the individuals, “responders”). The TNF-α secretion was reduced to 67.4, 68.0, 63.6, and 67.1% of the initial values in responders. The effects in both patients and healthy persons were the same. Interindividual responses to LAs were not correlated with the duration or type of complaints, basal TNF-α serum level, sex, BMI, or age of responders. Conclusions. Four clinically relevant LAs (amid-LA and ester-LA) attenuate the inflammatory response provoked by LPS. They are potential candidates for drug repositioning in treating overactive immune reactions and chronic inflammation.