Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Grobholz, Rainer [VerfasserIn]  |
| Zentgraf, Hanswalter [VerfasserIn]  |
| Köhrmann, Kai-Uwe [VerfasserIn]  |
| Bleyl, Uwe [VerfasserIn]  |
Titel: | Bax, Bcl-2, Fas and Fas-L antigen expression in human seminoma |
Titelzusatz: | correlation with the apoptotic index |
Verf.angabe: | Rainer Grobholz, Hanswalter Zentgraf, Kai-Uwe Köhrmann and Uwe Bleyl |
E-Jahr: | 2003 |
Jahr: | 14 February 2003 |
Jahr des Originals: | 2002 |
Umfang: | 9 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 08.06.2022 |
Titel Quelle: | Enthalten in: Acta pathologica, microbiologica et immunologica Scandinavica |
Ort Quelle: | Oxford : Wiley-Blackwell, 1988 |
Jahr Quelle: | 2002 |
Band/Heft Quelle: | 110(2002), 10 vom: Okt., Seite 724-732 |
ISSN Quelle: | 1600-0463 |
Abstract: | Apoptosis plays a crucial role in the regulation of spermatogenesis in male germ cells and is, at least in part, modulated by Bcl-2, Bax, and the Fas pathway. Seminomas have a favourable outcome and respond to radio-/chemotherapy with an increased rate of apoptosis. The expression of Bax, Bcl-2, Fas and Fas-ligand (Fas-L) in human seminoma was evaluated and correlated with the apoptotic index. Twenty-nine classical seminomas were examined by immunohistochemistry and Western blotting using antibodies against Bax, Bcl-2, Fas and Fas-L. Apoptosis was detected by in-situ end-labeling of fragmented DNA and the apoptotic index (AI) was determined. Expression of Fas was found in 26 (89.7%) of Fas-L in 24 seminomas (82.2%); none of the tumours expressed Bcl-2. No correlation between the AI and Fas, Fas-L or Bcl-2 expression was found. Bax was demonstrated in 20/29 tumours (69%). Bax-positive tumours showed an increased AI of 4.75±2.38% in contrast to 2.60±1.23% of the Bax-negative tumours (P=0.002). The number of Bax-positive tumour cells and apoptotic cells revealed a significant correlation using χ2-test (P=0.04) and linear regression (r=0.54, P=0.001). Therefore, Bax seems to play a determinant role in the modulation of apoptosis in human seminoma that may be linked to a favourable outcome. |
DOI: | doi:10.1034/j.1600-0463.2002.1101006.x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1034/j.1600-0463.2002.1101006.x |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1600-0463.2002.1101006.x |
| DOI: https://doi.org/10.1034/j.1600-0463.2002.1101006.x |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | apoptosis |
| Bax |
| Bcl-2 |
| Fas |
| Fas-L. |
| Seminoma |
K10plus-PPN: | 1806240831 |
Verknüpfungen: | → Zeitschrift |
Bax, Bcl-2, Fas and Fas-L antigen expression in human seminoma / Grobholz, Rainer [VerfasserIn]; 14 February 2003 (Online-Ressource)
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