| |  Online-Ressource |
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| Verfasst von: | Ni, Ming [VerfasserIn]  |
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| | Wang, Lei [VerfasserIn] |
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| | Ding, Yuntian [VerfasserIn] |
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| | Gong, Wenjie [VerfasserIn] |
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| | Wang, Sanmei [VerfasserIn] |
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| | Neuber, Brigitte [VerfasserIn] |
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| | Schubert, Maria-Luisa [VerfasserIn] |
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| | Sauer, Tim [VerfasserIn] |
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| | Hückelhoven-Krauss, Angela [VerfasserIn] |
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| | Luft, Thomas [VerfasserIn] |
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| | Hegenbart, Ute [VerfasserIn] |
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| | Schönland, Stefan [VerfasserIn] |
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| | Eckstein, Volker [VerfasserIn] |
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| | Wang, Jishi [VerfasserIn] |
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| | Krüger, William [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Schmitt, Michael [VerfasserIn] |
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| | Schmitt, Anita [VerfasserIn] |
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| Titel: | Response to extracorporeal photopheresis therapy of patients with steroid-refractory/-resistant GvHD is associated with up-regulation of Th22 cells and Tfh cells |
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| Verf.angabe: | Ming Ni, Lei Wang, Yuntian Ding, Wenjie Gong, Sanmei Wang, Brigitte Neuber, Maria-Luisa Schubert, Tim Sauer, Angela Hückelhoven-Krauss, Thomas Luft, Ute Hegenbart, Stefan Schönland, Volker Eckstein, Jishi Wang, William Krüger, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt |
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| E-Jahr: | 2022 |
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| Jahr: | March 2022 |
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| Umfang: | 9 S. |
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| Fussnoten: | Available online 25 October 2021 ; Gesehen am 08.06.2022 |
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| Titel Quelle: | Enthalten in: Cytotherapy |
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| Ort Quelle: | Abingdon : Taylor & Francis Group, 1999 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 24(2022), 3, Seite 311-319 |
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| ISSN Quelle: | 1477-2566 |
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| Abstract: | Extracorporeal photopheresis (ECP), a personalized cellular immunotherapy, constitutes a promising treatment for steroid-refractory/-resistant graft-versus-host disease (SR-GvHD), with encouraging clinical response rates. To further investigate its mechanism of action, ECP's effects on T helper (Th) cells as well as on expression of immune checkpoint (PD-1 and Tim-3) and apoptotic (Fas receptor [FasR]) molecules were investigated in 27 patients with SR-GvHD. Our data show that GvHD patients had significantly higher levels of Th2, Th17, Th22 and granulocyte-macrophage colony-stimulating factor (GM-CSF)-positive Th (ThG) cells and clearly lower levels of T follicular helper (Tfh) cells, including Th1- and Th2-like cells, compared with healthy donors. ECP therapy for GvHD was effective through the modulation of different Th subsets: increases of Th22 (1.52-fold) and Tfh cells (1.48-fold) in acute GvHD (aGvHD) and increases of Th2-like Tfh cells (1.74-fold) in chronic GvHD (cGvHD) patients were associated with clinical response. Expression of FasR was further upregulated in CD4+CD8+ T cells. Additionally, Tim-3-expressing effector T cells associated with the severity of GvHD were reduced. Taken together, these data show that ECP therapy exerts immunomodulatory effects by promoting a balanced immune reconstitution and inducing immune tolerance. Therefore it represents an attractive option for the treatment of GvHD. |
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| DOI: | doi:10.1016/j.jcyt.2021.09.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jcyt.2021.09.008 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1465324921008227 |
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| | DOI: https://doi.org/10.1016/j.jcyt.2021.09.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ECP |
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| | Fas-mediated apoptosis |
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| | GvHD |
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| | immune checkpoint molecules |
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| | immunomodulation |
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| | Th cells |
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| K10plus-PPN: | 1806275678 |
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| Verknüpfungen: | → Zeitschrift |
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Response to extracorporeal photopheresis therapy of patients with steroid-refractory/-resistant GvHD is associated with up-regulation of Th22 cells and Tfh cells / Ni, Ming [VerfasserIn]; March 2022 (Online-Ressource)
