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| Verfasst von: | Vierthaler, Marlene [VerfasserIn]  |
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| | Sun, Qian [VerfasserIn] |
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| | Wang, Yiman [VerfasserIn] |
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| | Steinfass, Tamara [VerfasserIn] |
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| | Poelchen, Juliane [VerfasserIn] |
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| | Hielscher, Thomas [VerfasserIn] |
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| | Novak, Daniel [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| Titel: | ADCK2 knockdown affects the migration of melanoma cells via MYL6 |
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| Verf.angabe: | Marlene Vierthaler, Qian Sun, Yiman Wang, Tamara Steinfass, Juliane Poelchen, Thomas Hielscher, Daniel Novak, Viktor Umansky, Jochen Utikal |
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| E-Jahr: | 2022 |
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| Jahr: | 20 February 2022 |
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| Umfang: | 18 S. |
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| Fussnoten: | This article belongs to the Special Issue Epidemiology and Biological Features of Melanoma ; Gesehen am 09.06.2022 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 4, Artikel-ID 1071, Seite 1-18 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Background: ADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism. However, ADCKs have also been connected to cancer cell survival, proliferation and motility. In this study, we investigated the role of ADCK2 in melanoma. Methods: The effect of ADCK2 on melanoma cell motility was evaluated by a scratch assay and a transwell invasion assay upon siRNA-mediated knockdown or stable overexpression of ADCK2. Results: We found that high levels of intratumoral ADCK2 and MYL6 are associated with a higher survival rate in melanoma patients. Knocking down ADCK2 resulted in enhanced cell migration of melanoma cells. Moreover, ADCK2-knockdown cells adopted a more dedifferentiated phenotype. A gene expression array revealed that the expression of ADCK2 correlated with the expressions of MYL6 and RAB2A. Knocking down MYL6 in ADCK2-overexpressing cells could abrogate the effect of ADCK2 overexpression and thus confirm the functional connection between ADCK2 and MYL6. Conclusion: ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma. |
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| DOI: | doi:10.3390/cancers14041071 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers14041071 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/14/4/1071 |
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| | DOI: https://doi.org/10.3390/cancers14041071 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADCK2 |
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| | cancer |
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| | melanoma |
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| | motility |
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| | MYL6 |
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| K10plus-PPN: | 1806534398 |
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| Verknüpfungen: | → Zeitschrift |
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ADCK2 knockdown affects the migration of melanoma cells via MYL6 / Vierthaler, Marlene [VerfasserIn]; 20 February 2022 (Online-Ressource)
