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| Verfasst von: | Neuenfeldt, Friederike S. [VerfasserIn]  |
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| | Schumacher, Jan-Christoph [VerfasserIn] |
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| | Grieshaber-Bouyer, Ricardo [VerfasserIn] |
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| | Habicht, Jüri [VerfasserIn] |
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| | Schröder-Braunstein, Jutta [VerfasserIn] |
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| | Gauss, Annika [VerfasserIn] |
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| | Merle, Uta [VerfasserIn] |
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| | Niesler, Beate [VerfasserIn] |
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| | Heineken, Niko [VerfasserIn] |
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| | Dalpke, Alexander [VerfasserIn] |
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| | Gaida, Matthias M. [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| | Meuer, Stefan [VerfasserIn] |
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| | Samstag, Yvonne [VerfasserIn] |
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| | Wabnitz, Guido H. [VerfasserIn] |
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| Titel: | Inflammation induces pro-NETotic neutrophils via TNFR2 signaling |
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| Verf.angabe: | Friederike Neuenfeldt, Jan Christoph Schumacher, Ricardo Grieshaber-Bouyer, Jüri Habicht, Jutta Schröder-Braunstein, Annika Gauss, Uta Merle, Beate Niesler, Niko Heineken, Alexander Dalpke, Matthias M. Gaida, Thomas Giese, Stefan Meuer, Yvonne Samstag, and Guido Wabnitz |
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| E-Jahr: | 2022 |
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| Jahr: | April 19, 2022 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 09.06.2022 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 39(2022), 3, Artikel-ID 110710, Seite 1-22 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Cytokines released during chronic inflammatory diseases induce pro-inflammatory properties in polymorphonuclear neutrophils (PMNs). Here, we describe the development of a subgroup of human PMNs expressing CCR5, termed CCR5+ PMNs. Auto- and paracrine tumor necrosis factor (TNF) signaling increases intracellular neutrophil elastase (ELANE) abundance and induces neutrophil extracellular traps formation (NETosis) in CCR5+ PMNs, and triggering of CCR5 amplifies NETosis. Membranous TNF (mTNF) outside-in signaling induces the formation of reactive oxygen species, known activators of NETosis. In vivo, we find an increased number of CCR5+ PMNs in the peripheral blood and inflamed lamina propria of patients with ulcerative colitis (UC). Notably, failure of anti-TNF therapy is associated with higher frequencies of CCR5+ PMNs. In conclusion, we identify a phenotype of pro-NETotic, CCR5+ PMNs present in inflamed tissue in vivo and inducible in vitro. These cells may reflect an important component of tissue damage during chronic inflammation and could be of diagnostic value. |
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| DOI: | doi:10.1016/j.celrep.2022.110710 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1016/j.celrep.2022.110710 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722004715 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.110710 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | NETosis |
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| | neutrophil diversification |
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| | neutrophil subgroups |
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| | neutrophils |
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| | retrograde TNF signaling |
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| | ulcerative colitis |
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| K10plus-PPN: | 1806559390 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Inflammation induces pro-NETotic neutrophils via TNFR2 signaling / Neuenfeldt, Friederike S. [VerfasserIn]; April 19, 2022 (Online-Ressource)
