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| Verfasst von: | Dieter, Sebastian M. [VerfasserIn]  |
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| | Ball, Claudia R. [VerfasserIn] |
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| | Hoffmann, Christopher M. [VerfasserIn] |
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| | Nowrouzi, Ali [VerfasserIn] |
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| | Herbst, Friederike [VerfasserIn] |
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| | Zavidij, Oksana [VerfasserIn] |
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| | Abel, Ulrich [VerfasserIn] |
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| | Arens, Anne [VerfasserIn] |
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| | Weichert, Wilko [VerfasserIn] |
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| | Brand, Karsten [VerfasserIn] |
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| | Koch, Moritz [VerfasserIn] |
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| | Weitz, Jürgen [VerfasserIn] |
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| | Schmidt, Manfred [VerfasserIn] |
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| | Kalle, Christof von [VerfasserIn] |
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| | Glimm, Hanno [VerfasserIn] |
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| Titel: | Distinct types of tumor-initiating cells form human colon cancer tumors and metastases |
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| Verf.angabe: | Sebastian M. Dieter, Claudia R. Ball, Christopher M. Hoffmann, Ali Nowrouzi, Friederike Herbst, Oksana Zavidij, Ulrich Abel, Anne Arens, Wilko Weichert, Karsten Brand, Moritz Koch, Jürgen Weitz, Manfred Schmidt, Christof von Kalle, and Hanno Glimm |
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| E-Jahr: | 2011 |
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| Jahr: | October 7, 2011 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 10.06.2022 |
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| Titel Quelle: | Enthalten in: Cell stem cell |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 9(2011), 4, Seite 357-365 |
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| ISSN Quelle: | 1875-9777 |
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| Abstract: | Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population driving tumor maintenance and metastasis formation. We found unexpected cellular heterogeneity within the TIC compartment, which contains three types of TICs. Extensively self-renewing long-term TICs (LT-TICs) maintained tumor formation in serial xenotransplants. Tumor transient amplifying cells (T-TACs) with limited or no self-renewal capacity contributed to tumor formation only in primary mice. Rare delayed contributing TICs (DC-TICs) were exclusively active in secondary or tertiary mice. Bone marrow was identified as an important reservoir of LT-TICs. Metastasis formation was almost exclusively driven by self-renewing LT-TICs. Our results demonstrate that tumor initiation, self-renewal, and metastasis formation are limited to particular subpopulations of TICs in primary human colon cancer. We identify LT-TICs as a quantifiable target for therapies aimed toward eradication of self-renewing tumorigenic and metastatic colon cancer cells. |
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| DOI: | doi:10.1016/j.stem.2011.08.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.stem.2011.08.010 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1934590911003912 |
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| | DOI: https://doi.org/10.1016/j.stem.2011.08.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1806777657 |
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| Verknüpfungen: | → Zeitschrift |
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Distinct types of tumor-initiating cells form human colon cancer tumors and metastases / Dieter, Sebastian M. [VerfasserIn]; October 7, 2011 (Online-Ressource)
