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| Verfasst von: | Dögel, Daniela [VerfasserIn]  |
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| | Müller, Wolf C. [VerfasserIn] |
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| | Deckert, Martina [VerfasserIn] |
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| | Lenhard, Thorsten [VerfasserIn] |
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| | Schmidt-Bacher, Annette [VerfasserIn] |
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| | Storch-Hagenlocher, Brigitte [VerfasserIn] |
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| | Biller, Armin [VerfasserIn] |
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| | Wildemann, Brigitte [VerfasserIn] |
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| Titel: | An unusual case of optic neuritis |
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| Verf.angabe: | Daniela Doegel, Wolf Mueller, Martina Deckert, Thorsten Lenhard, Annette Schmidt-Bacher, Brigitte Storch-Hagenlocher, Armin Biller, Brigitte Wildemann |
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| E-Jahr: | 2011 |
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| Jahr: | 15 May 2011 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 14.06.2022 |
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| Titel Quelle: | Enthalten in: Journal of neurological sciences |
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| Ort Quelle: | Izmir : Soc., 1998 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 304(2011), Seite 138-141 |
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| ISSN Quelle: | 1302-1664 |
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| Abstract: | Optic neuritis is a frequent disease with well established tests and therapeutic strategies. However, possible differential diagnoses cover a broad spectrum. Therefore, clinical work-up can be challenging and routine testing and therapies may not be sufficient. In this case, a 26year old female is described who presented with clinical features of optic neuritis, yet failed to respond to common therapeutic strategies and lost vision on the affected eye. Diagnostic nerve transection was performed, histopathology suggested inflammation. As the second nerve became affected, immunosuppressive therapy with cyclophosphamide was started and stopped further deterioration. Although additional molecular work-up of the transected nerve revealed clonal rearrangement of the B-cell-receptor-locus IgH, overall histopathologic features and the absence of systemic disease suggested an aggressive inflammatory process rather than lymphoma. Additional B-cell depletion with rituximab prompted significant and sustained visual improvement. This case emphasizes the necessity to consider rare differential diagnoses of optic neuritis, when uncommon features arise during the course of disease. Aggressive immunosuppression might be required to achieve stable improvement of vision. |
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| DOI: | doi:10.1016/j.jns.2011.02.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jns.2011.02.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0022510X11000621 |
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| | DOI: https://doi.org/10.1016/j.jns.2011.02.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Immunosuppression |
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| | Multiple sclerosis |
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| | Neuroimmunology |
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| | Neuroophthalmology |
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| | Optic neuritis |
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| K10plus-PPN: | 1806973057 |
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| Verknüpfungen: | → Zeitschrift |
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¬An¬ unusual case of optic neuritis / Dögel, Daniela [VerfasserIn]; 15 May 2011 (Online-Ressource)
