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Verfasst von:Dögel, Daniela [VerfasserIn]   i
 Müller, Wolf C. [VerfasserIn]   i
 Deckert, Martina [VerfasserIn]   i
 Lenhard, Thorsten [VerfasserIn]   i
 Schmidt-Bacher, Annette [VerfasserIn]   i
 Storch-Hagenlocher, Brigitte [VerfasserIn]   i
 Biller, Armin [VerfasserIn]   i
 Wildemann, Brigitte [VerfasserIn]   i
Titel:An unusual case of optic neuritis
Verf.angabe:Daniela Doegel, Wolf Mueller, Martina Deckert, Thorsten Lenhard, Annette Schmidt-Bacher, Brigitte Storch-Hagenlocher, Armin Biller, Brigitte Wildemann
E-Jahr:2011
Jahr:15 May 2011
Umfang:4 S.
Fussnoten:Gesehen am 14.06.2022
Titel Quelle:Enthalten in: Journal of neurological sciences
Ort Quelle:Izmir : Soc., 1998
Jahr Quelle:2011
Band/Heft Quelle:304(2011), Seite 138-141
ISSN Quelle:1302-1664
Abstract:Optic neuritis is a frequent disease with well established tests and therapeutic strategies. However, possible differential diagnoses cover a broad spectrum. Therefore, clinical work-up can be challenging and routine testing and therapies may not be sufficient. In this case, a 26year old female is described who presented with clinical features of optic neuritis, yet failed to respond to common therapeutic strategies and lost vision on the affected eye. Diagnostic nerve transection was performed, histopathology suggested inflammation. As the second nerve became affected, immunosuppressive therapy with cyclophosphamide was started and stopped further deterioration. Although additional molecular work-up of the transected nerve revealed clonal rearrangement of the B-cell-receptor-locus IgH, overall histopathologic features and the absence of systemic disease suggested an aggressive inflammatory process rather than lymphoma. Additional B-cell depletion with rituximab prompted significant and sustained visual improvement. This case emphasizes the necessity to consider rare differential diagnoses of optic neuritis, when uncommon features arise during the course of disease. Aggressive immunosuppression might be required to achieve stable improvement of vision.
DOI:doi:10.1016/j.jns.2011.02.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.jns.2011.02.007
 Volltext: https://www.sciencedirect.com/science/article/pii/S0022510X11000621
 DOI: https://doi.org/10.1016/j.jns.2011.02.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Immunosuppression
 Multiple sclerosis
 Neuroimmunology
 Neuroophthalmology
 Optic neuritis
K10plus-PPN:1806973057
Verknüpfungen:→ Zeitschrift

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