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Status: Bibliographieeintrag

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Verfasst von:Schaub, Meike [VerfasserIn]   i
 Plötz, Christian J. [VerfasserIn]   i
 Gerbaulet, Daniel [VerfasserIn]   i
 Fang, Liu [VerfasserIn]   i
 Kranich, Pia [VerfasserIn]   i
 Stadlbauer, Thomas H. W. [VerfasserIn]   i
 Göttmann, Uwe [VerfasserIn]   i
 Yard, Benito A. [VerfasserIn]   i
 Braun, Claude [VerfasserIn]   i
 Schnülle, Peter [VerfasserIn]   i
 Woude, Fokko J. van der [VerfasserIn]   i
Titel:Effect of dopamine on inflammatory status in kidneys of brain-dead rats
Verf.angabe:Meike Schaub, Christian J. Ploetz, Daniel Gerbaulet, Liu Fang, Pia Kranich, Thomas H. W. Stadlbauer, Uwe Goettman, Benito A. Yard, Claude Braun, Peter Schnuelle, Fokko J. van der Woude
Jahr:2004
Umfang:8 S.
Fussnoten:Gesehen am 22.06.2022
Titel Quelle:Enthalten in: Transplantation
Ort Quelle:Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
Jahr Quelle:2004
Band/Heft Quelle:77(2004), 9, Seite 1333-1340
ISSN Quelle:1534-6080
Abstract:BACKGROUND: Brain death has been identified as an independent risk factor for chronic allograft dysfunction. In two independent retrospective clinical studies, we showed that dopamine treatment of brain-dead donors improves long-term kidney graft survival. The mechanisms underlying the protective effects of dopamine treatment in vivo have not been identified. To elucidate the mechanisms underlying the protective effect of dopamine on kidneys of brain-dead donors, we studied a model for brain death in rats. METHODS: In F344 rats, brain death was induced by epidural inflation of a 3F Fogarty catheter. Apneic animals were mechanically ventilated, and clinically relevant dosages of dopamine (2, 6, 10, or 14 microg/kg/min) were given for 6 hr from the onset of brain death. Ventilated, non-brain-dead animals served as controls. RESULTS: Dopamine significantly reduced renal monocyte infiltration and major histocompatibility class II and P-selectin expression in brain-dead animals. It also prevented further up-regulation of the inflammatory markers tumor necrosis factor-alpha and monocyte chemoattractant peptide-1. Concomitantly, the presence of inducible anti-oxidant heme oxygenase-1, known for its cytoprotective effects, was strongly increased by dopamine. CONCLUSION: We identified several mechanisms underlying the protective effects of dopamine treatment on kidney grafts. The identification of these mechanisms may help to design more effective future strategies for treatment of cadaveric kidney donors.
DOI:doi:10.1097/01.tp.0000119164.47302.49
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/01.tp.0000119164.47302.49
 Volltext: https://journals.lww.com/transplantjournal/Fulltext/2004/05150/EFFECT_OF_DOPAMINE_ON_INFLAMMATORY_STATUS_IN.5.aspx
 DOI: https://doi.org/10.1097/01.tp.0000119164.47302.49
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Animals
 Blood Pressure
 Blotting, Western
 Brain Death
 Dopamine
 Gene Expression
 Heme Oxygenase (Decyclizing)
 Heme Oxygenase-1
 Kidney
 Kidney Transplantation
 Male
 Nephritis
 Oxidative Stress
 Rats
 Rats, Inbred F344
 Reverse Transcriptase Polymerase Chain Reaction
 Tissue Donors
 Tumor Necrosis Factor-alpha
K10plus-PPN:1807460851
Verknüpfungen:→ Zeitschrift

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