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| Verfasst von: | Kriz, Wilhelm [VerfasserIn]  |
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| | Hähnel, Brunhilde [VerfasserIn] |
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| | Hosser, Hiltraud [VerfasserIn] |
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| | Ostendorf, Tammo [VerfasserIn] |
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| | Gaertner, Soeren [VerfasserIn] |
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| | Kränzlin, Bettina [VerfasserIn] |
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| | Gretz, Norbert [VerfasserIn] |
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| | Shimizu, Fujio [VerfasserIn] |
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| | Floege, Jürgen [VerfasserIn] |
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| Titel: | Pathways to recovery and loss of nephrons in Anti-Thy-1 nephritis |
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| Verf.angabe: | Wilhelm Kriz, Bruni Hähnel, Hiltraud Hosser, Tammo Ostendorf, Soeren Gaertner, Bettina Kränzlin, Norbert Gretz, Fujio Shimizu, and Jürgen Floege |
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| E-Jahr: | 2003 |
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| Jahr: | [July 2003] |
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| Umfang: | 23 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 22.06.2022 |
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| Titel Quelle: | Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology |
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| Ort Quelle: | Washington, DC : American Society of Nephrology, 1990 |
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| Jahr Quelle: | 2003 |
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| Band/Heft Quelle: | 14(2003), 7 vom: Juli, Seite 1904-1926 |
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| ISSN Quelle: | 1533-3450 |
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| Abstract: | ABSTRACT. The present histopathologic study of anti-Thy-1.1 models of mesangioproliferative glomerulonephritis in rats provides a structural analysis of damage development and of pathways to recovery and to nephron loss. As long as the disease remains confined to the endocapillary compartment, the damage may be resolved or recover with a mesangial scar. Irreversible lesions with loss of nephrons emerge from extracapillary processes with crucial involvement of podocytes, leading to tuft adhesions to Bowman‘s capsule (BC) and subsequent crescent formation. Two mechanisms appeared to be responsible: (1) Epithelial cell proliferation at BC and the urinary orifice and (2) misdirected filtration and filtrate spreading on the outer aspect of the nephron. Both may lead to obstruction of the tubule, disconnection from the glomerulus, and subsequent degeneration of the entire nephron. No evidence emerged to suggest that the kind of focal interstitial proliferation associated with the degeneration of injured nephrons was harmful to a neighboring healthy nephron. E-mail: wilhelm.krizurz.uni-heidelberg.de |
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| DOI: | doi:10.1097/01.ASN.0000070073.79690.57 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/01.ASN.0000070073.79690.57 |
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| | Volltext: https://jasn.asnjournals.org/content/14/7/1904 |
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| | DOI: https://doi.org/10.1097/01.ASN.0000070073.79690.57 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1807476510 |
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| Verknüpfungen: | → Zeitschrift |
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Pathways to recovery and loss of nephrons in Anti-Thy-1 nephritis / Kriz, Wilhelm [VerfasserIn]; [July 2003] (Online-Ressource)
