Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Hildenbrand, Ralf [VerfasserIn]  |
| Wolf, Georg [VerfasserIn]  |
| Böhme, Beatrix [VerfasserIn]  |
| Bleyl, Uwe [VerfasserIn]  |
| Steinborn, Andrea [VerfasserIn]  |
Titel: | Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue |
Verf.angabe: | Ralf Hildenbrand, Georg Wolf, Beatrix Böhme, Uwe Bleyl, and Andrea Steinborn |
E-Jahr: | 1999 |
Jahr: | 01 July 1999 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 23.06.2022 |
Titel Quelle: | Enthalten in: Journal of leukocyte biology |
Ort Quelle: | Kettering : Oxford University Press, 1984 |
Jahr Quelle: | 1999 |
Band/Heft Quelle: | 66(1999), 1, Seite 40-49 |
ISSN Quelle: | 1938-3673 |
Abstract: | Macrophages concentrate urokinase-type plasminogen activator (uPA) at the cell surface by expressing urokinase receptors (uPAR) in order to focus the pericellular space plasminogen-dependent proteolysis important in matrix remodeling and cell movement. This study examines the uPAR levels of tumor-associated macrophages (TAM) of invasive breast carcinomas, of TAMs from ductal carcinoma in situ (DCIS) and of macrophages derived from normal (non-tumor) breast tissue. TAMs from invasive breast carcinomas (n = 30), from DCIS (n = 12), and macrophages from normal breast tissue (n = 30) were cultured and immunocytochemically phenotyped by using a panel of antibodies. Urokinase receptor levels were determined by Western blot analysis and in cell-free supernatants by enzyme-linked immunosorbent assay. Urokinase receptor cell surface fluorescence intensity was determined by FACS and by confocal laser scan microscopy. Urokinase-receptor mRNA was detected by in situ hybridization. TAMs of invasive breast carcinomas and of DCIS possess significantly elevated uPAR levels compared with macrophages derived from normal breast tissue. Conclusions: activated macrophages with elevated uPAR levels belong to inflammatory areas in close vicinity of infiltrating and non-infiltrating (DCIS) tumor cells. Blood monocytes that possess elevated uPAR-levels may be selectively recruited from the bloodstream to inflammatory sites close to carcinoma cells, and/or breast cancer and precursor lesions may induce elevated uPAR-levels in TAMs by paracrine interactions. J. Leukoc. Biol. 66: 40-49; 1999. |
DOI: | doi:10.1002/jlb.66.1.40 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/jlb.66.1.40 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jlb.66.1.40 |
| DOI: https://doi.org/10.1002/jlb.66.1.40 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | blood monocytes |
| inflammation |
| urokinase receptor |
K10plus-PPN: | 1807531252 |
Verknüpfungen: | → Zeitschrift |
Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue / Hildenbrand, Ralf [VerfasserIn]; 01 July 1999 (Online-Ressource)
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