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Verfasst von:Hildenbrand, Ralf [VerfasserIn]   i
 Wolf, Georg [VerfasserIn]   i
 Böhme, Beatrix [VerfasserIn]   i
 Bleyl, Uwe [VerfasserIn]   i
 Steinborn, Andrea [VerfasserIn]   i
Titel:Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue
Verf.angabe:Ralf Hildenbrand, Georg Wolf, Beatrix Böhme, Uwe Bleyl, and Andrea Steinborn
E-Jahr:1999
Jahr:01 July 1999
Umfang:10 S.
Fussnoten:Gesehen am 23.06.2022
Titel Quelle:Enthalten in: Journal of leukocyte biology
Ort Quelle:Kettering : Oxford University Press, 1984
Jahr Quelle:1999
Band/Heft Quelle:66(1999), 1, Seite 40-49
ISSN Quelle:1938-3673
Abstract:Macrophages concentrate urokinase-type plasminogen activator (uPA) at the cell surface by expressing urokinase receptors (uPAR) in order to focus the pericellular space plasminogen-dependent proteolysis important in matrix remodeling and cell movement. This study examines the uPAR levels of tumor-associated macrophages (TAM) of invasive breast carcinomas, of TAMs from ductal carcinoma in situ (DCIS) and of macrophages derived from normal (non-tumor) breast tissue. TAMs from invasive breast carcinomas (n = 30), from DCIS (n = 12), and macrophages from normal breast tissue (n = 30) were cultured and immunocytochemically phenotyped by using a panel of antibodies. Urokinase receptor levels were determined by Western blot analysis and in cell-free supernatants by enzyme-linked immunosorbent assay. Urokinase receptor cell surface fluorescence intensity was determined by FACS and by confocal laser scan microscopy. Urokinase-receptor mRNA was detected by in situ hybridization. TAMs of invasive breast carcinomas and of DCIS possess significantly elevated uPAR levels compared with macrophages derived from normal breast tissue. Conclusions: activated macrophages with elevated uPAR levels belong to inflammatory areas in close vicinity of infiltrating and non-infiltrating (DCIS) tumor cells. Blood monocytes that possess elevated uPAR-levels may be selectively recruited from the bloodstream to inflammatory sites close to carcinoma cells, and/or breast cancer and precursor lesions may induce elevated uPAR-levels in TAMs by paracrine interactions. J. Leukoc. Biol. 66: 40-49; 1999.
DOI:doi:10.1002/jlb.66.1.40
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/jlb.66.1.40
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jlb.66.1.40
 DOI: https://doi.org/10.1002/jlb.66.1.40
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:blood monocytes
 inflammation
 urokinase receptor
K10plus-PPN:1807531252
Verknüpfungen:→ Zeitschrift

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