Spatial distribution and long-term alterations of peripheral nerve lesions in schwannomatosis

• Verfasst von: Godel, Tim [VerfasserIn]
• Verfasst von: Bäumer, Philipp [VerfasserIn]
• Verfasst von: Farschtschi, Said [VerfasserIn]
• Verfasst von: Hofstadler, Barbara [VerfasserIn]
• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Gelderblom, Mathias [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Mautner, Victor-Felix [VerfasserIn]
• Titel: Spatial distribution and long-term alterations of peripheral nerve lesions in schwannomatosis
• Verf.angabe: Tim Godel, Philipp Bäumer, Said Farschtschi, Barbara Hofstadler, Sabine Heiland, Mathias Gelderblom, Martin Bendszus and Victor-Felix Mautner
• E-Jahr: 2022
• Jahr: 23 March 2022
• Umfang: 11 S.
• Fussnoten: This article belongs to the Special issue: The Diagnostic Value of Nerve and Muscle Ultrasound in Neuromuscular Disorders ; Gesehen am 23.06.2022
• Titel Quelle: Enthalten in: Diagnostics
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), 4, Special issue vom: Apr., Artikel-ID 780, Seite 1-11
• ISSN Quelle: 2075-4418
• DOI: doi:10.3390/diagnostics12040780
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: magnetic resonance neurography
• Sach-SW: peripheral nerve lesions
• Sach-SW: schwannomatosis
• Sach-SW: small fiber neuropathy
• K10plus-PPN: 1807553310

Abstract

Purpose: To examine the spatial distribution and long-term alterations of peripheral nerve lesions in patients with schwannomatosis by in vivo high-resolution magnetic resonance neurography (MRN). Methods: In this prospective study, the lumbosacral plexus as well as the right sciatic, tibial, and peroneal nerves were examined in 15 patients diagnosed with schwannomatosis by a standardized MRN protocol at 3 Tesla. Micro-, intermediate- and macrolesions were assessed according to their number, diameter and spatial distribution. Moreover, in nine patients, peripheral nerve lesions were compared to follow-up examinations after 39 to 71 months. Results: In comparison to intermediate and macrolesions, microlesions were the predominant lesion entity at the level of the proximal (p < 0.001), mid- (p < 0.001), and distal thigh (p < 0.01). Compared to the proximal calf level, the lesion number was increased at the proximal (p < 0.05), mid- (p < 0.01), and distal thigh level (p < 0.01), while between the different thigh levels, no differences in lesion numbers were found. In the follow-up examinations, the lesion number was unchanged for micro-, intermediate and macrolesions. The diameter of lesions in the follow-up examination was decreased for microlesions (p < 0.01), not different for intermediate lesions, and increased for macrolesions (p < 0.01). Conclusion: Microlesions represent the predominant type of peripheral nerve lesion in schwannomatosis and show a rather consistent distribution pattern in long-term follow-up. In contrast to the accumulation of nerve lesions, primarily in the distal nerve segments in NF2, the lesion numbers in schwannomatosis peak at the mid-thigh level. Towards more distal portions, the lesion number markedly decreases, which is considered as a general feature of other types of small fiber neuropathy.