Enucleation is a feasible procedure for well-differentiated pNEN

• Verfasst von: Nießen, Anna [VerfasserIn]
• Verfasst von: Bechtiger, Fabiola A. [VerfasserIn]
• Verfasst von: Hinz, Ulf [VerfasserIn]
• Verfasst von: Lewosinska, Magdalena [VerfasserIn]
• Verfasst von: Billmann, Franck [VerfasserIn]
• Verfasst von: Hackert, Thilo [VerfasserIn]
• Verfasst von: Büchler, Markus W. [VerfasserIn]
• Verfasst von: Schimmack, Simon [VerfasserIn]
• Titel: Enucleation is a feasible procedure for well-differentiated pNEN
• Titelzusatz: a matched pair analysis
• Verf.angabe: Anna Nießen, Fabiola A. Bechtiger, Ulf Hinz, Magdalena Lewosinska, Franck Billmann, Thilo Hackert, Markus W. Büchler and Simon Schimmack
• E-Jahr: 2022
• Jahr: 23 May 2022
• Umfang: 12 S.
• Fussnoten: Gesehen am 23.06.2022 ; This article belongs to the special issue "Updates on diagnostic and therapeutic management of neuroendocrine neoplasms"
• Titel Quelle: Enthalten in: Cancers
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2022
• Band/Heft Quelle: 14(2022), 10, special issue, Artikel-ID 2570, Seite 1-12
• ISSN Quelle: 2072-6694
• DOI: doi:10.3390/cancers14102570
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: enucleation
• Sach-SW: formal resection
• Sach-SW: neuroendocrine tumors
• Sach-SW: pNEN
• Sach-SW: surgery
• K10plus-PPN: 1807581489

Abstract

The extent of surgical resection in the treatment of pancreatic neuroendocrine neoplasms (pNEN) is still controversial. This study aimed to evaluate the outcomes of enucleation for well-differentiated non-functional (nf) pNEN. Patients undergoing enucleation (2001-2020) were analyzed. Clinicopathological parameters, perioperative outcomes and survival were assessed. The analysis was performed as a nested case-control study and matched-pair analysis with formal resection. Sixty-one patients undergoing enucleation were identified. Compared to patients undergoing formal resection, enucleation was associated with a significantly shorter median length of operative time (128 (IQR 95-170) versus 263 (172-337) minutes, p < 0.0001) and a significantly lower rate of postoperative diabetes (2% versus 21%, p = 0.0020). There was no significant difference in postoperative pancreatic fistula rate (18% versus 16% type B/C, p = 1.0), Clavien−Dindo ≥ III complications (20% versus 26%, p = 0.5189), readmission rate (12% versus 15%, p = 0.6022) or length of hospital stay (8 (7-11) versus 10 (8-17) days, p = 0.0652). There was no 30-day mortality after enucleation compared to 1.6% (n = 1) after formal resection. 10-year overall survival (OS) and disease-free survival (DFS) was similar between the two groups (OS: 89% versus 77%, p = 0.2756; DFS: 98% versus 91%, p = 0.0873). Enucleation presents a safe surgical approach for well-differentiated nf-pNEN with good long-term outcomes for selected patients.