Modular approach for modeling cell motility

• Verfasst von: Ziebert, Falko [VerfasserIn]
• Verfasst von: Aranson, Igor S. [VerfasserIn]
• Titel: Modular approach for modeling cell motility
• Verf.angabe: F. Ziebert and I.S. Aranson
• E-Jahr: 2014
• Jahr: 12 June 2014
• Umfang: 13 S.
• Fussnoten: Gesehen am 27.09.2022
• Titel Quelle: Enthalten in: European physical journal special topics
• Ort Quelle: Berlin : Springer, 2007
• Jahr Quelle: 2014
• Band/Heft Quelle: 223(2014), 7, Seite 1265-1277
• ISSN Quelle: 1951-6401
• DOI: doi:10.1140/epjst/e2014-02190-2
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Actin Polymerization
• Sach-SW: Adhesive Bond
• Sach-SW: European Physical Journal Special Topic
• Sach-SW: Internal Dynamic
• Sach-SW: Traction Force
• K10plus-PPN: 1807742547

Abstract

Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach that starts with a minimal model, consisting of a phase field description of the moving cell boundary and a simplified internal dynamics. We discuss how this starting point can be extended to increase the level of detail, and how the internal dynamics “module” can be changed/adjusted to properly model various cell types. The former route allows studying specific processes involved in cell motility in the framework of a self-organized moving domain, and the latter might permit to put different cellular motility mechanisms into a unified framework.