Using matrix-assisted laser desorption ionization-time of flight mass spectrometry to detect carbapenem resistance within 1 to 2.5 hours

• Verfasst von: Burckhardt, Irene [VerfasserIn]
• Verfasst von: Zimmermann, Stefan [VerfasserIn]
• Titel: Using matrix-assisted laser desorption ionization-time of flight mass spectrometry to detect carbapenem resistance within 1 to 2.5 hours
• Verf.angabe: Irene Burckhardt and Stefan Zimmermann
• E-Jahr: 2011
• Jahr: September 2011
• Umfang: 4 S.
• Fussnoten: Gesehen am 24.06.2022
• Titel Quelle: Enthalten in: Journal of clinical microbiology
• Ort Quelle: Washington, DC : Soc., 1975
• Jahr Quelle: 2011
• Band/Heft Quelle: 49(2011), 9, Seite 3321-3324
• ISSN Quelle: 1098-660X
• DOI: doi:10.1128/JCM.00287-11
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1807802736

Abstract

In recent years, the percentage of carbapenem-resistant bacteria has increased at an alarming pace and become a major threat for patient survival. Carbapenemase-induced carbapenem resistance can be confirmed through the detection of carbapenem degradation using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). This method works for strains carrying NDM-1, VIM-1, VIM-2, KPC-2, and different IMP enzymes.