| |  Online-Ressource |
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| Verfasst von: | Haddock, Sara [VerfasserIn]  |
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| | Alban, Tyler J. [VerfasserIn] |
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| | Turcan, S̨evin [VerfasserIn] |
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| | Husic, Hana [VerfasserIn] |
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| | Rosiek, Eric [VerfasserIn] |
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| | Ma, Xiaoxiao [VerfasserIn] |
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| | Wang, Yuxiang [VerfasserIn] |
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| | Bale, Tejus [VerfasserIn] |
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| | Desrichard, Alexis [VerfasserIn] |
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| | Makarov, Vladimir [VerfasserIn] |
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| | Monette, Sebastien [VerfasserIn] |
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| | Wu, Wei [VerfasserIn] |
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| | Gardner, Rui [VerfasserIn] |
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| | Manova, Katia [VerfasserIn] |
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| | Boire, Adrienne [VerfasserIn] |
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| | Chan, Timothy A. [VerfasserIn] |
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| Titel: | Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells |
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| Verf.angabe: | Sara Haddock; Tyler J. Alban; Şevin Turcan; Hana Husic; Eric Rosiek; Xiaoxiao Ma; Yuxiang Wang; Tejus Bale; Alexis Desrichard; Vladimir Makarov; Sebastien Monette; Wei Wu; Rui Gardner; Katia Manova; Adrienne Boire; Timothy A. Chan |
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| E-Jahr: | 2022 |
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| Jahr: | June 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Available online 7 April 2022 ; Gesehen am 24.06.2022 |
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| Titel Quelle: | Enthalten in: Neoplasia |
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| Ort Quelle: | Basingstoke : Stockton Press, 1999 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 28(2022), Artikel-ID 100790, Seite 1-14 |
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| ISSN Quelle: | 1476-5586 |
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| Abstract: | Mutations in IDH1 and IDH2 drive the development of gliomas. These genetic alterations promote tumor cell renewal, disrupt differentiation states, and induce stem-like properties. Understanding how this phenotypic reprogramming occurs remains an area of high interest in glioma research. Previously, we showed that IDH mutation results in the development of a CD24-positive cell population in gliomas. Here, we demonstrate that this CD24-positive population possesses striking stem-like properties at the molecular and phenotypic levels. We found that CD24 expression is associated with stem-like features in IDH-mutant tumors, a patient-derived gliomasphere model, and a neural stem cell model of IDH1-mutant glioma. In orthotopic models, CD24-positive cells display enhanced tumor initiating potency compared to CD24-negative cells. Furthermore, CD24 knockdown results in changes in cell viability, proliferation rate, and gene expression that closely resemble a CD24-negative phenotype. Our data demonstrate that induction of a CD24-positive population is one mechanism by which IDH-mutant tumors acquire stem-like properties. These findings have significant implications for our understanding of the molecular underpinnings of IDH-mutant gliomas. |
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| DOI: | doi:10.1016/j.neo.2022.100790 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neo.2022.100790 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1476558622000197 |
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| | DOI: https://doi.org/10.1016/j.neo.2022.100790 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer stem cells |
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| | CD24 |
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| | IDH1 mutation |
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| | Low-grade glioma |
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| | Neural stem cells |
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| | Orthotopic mouse model |
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| K10plus-PPN: | 1807814939 |
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| Verknüpfungen: | → Zeitschrift |
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Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells / Haddock, Sara [VerfasserIn]; June 2022 (Online-Ressource)
