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Verfasst von:Ziebert, Falko [VerfasserIn]   i
 Aranson, Igor S. [VerfasserIn]   i
Titel:Effects of adhesion dynamics and substrate compliance on the shape and motility of crawling cells
Verf.angabe:Falko Ziebert, Igor S. Aranson
E-Jahr:2013
Jahr:May 31, 2013
Umfang:14 S.
Fussnoten:Gesehen am 27.09.2022
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2013
Band/Heft Quelle:8(2013), 5, Artikel-ID e64511, Seite 1-14
ISSN Quelle:1932-6203
Abstract:Computational modeling of eukaryotic cells moving on substrates is an extraordinarily complex task: many physical processes, such as actin polymerization, action of motors, formation of adhesive contacts concomitant with both substrate deformation and recruitment of actin etc., as well as regulatory pathways are intertwined. Moreover, highly nontrivial cell responses emerge when the substrate becomes deformable and/or heterogeneous. Here we extended a computational model for motile cell fragments, based on an earlier developed phase field approach, to account for explicit dynamics of adhesion site formation, as well as for substrate compliance via an effective elastic spring. Our model displays steady motion vs. stick-slip transitions with concomitant shape oscillations as a function of the actin protrusion rate, the substrate stiffness, and the rates of adhesion. Implementing a step in the substrate’s elastic modulus, as well as periodic patterned surfaces exemplified by alternating stripes of high and low adhesiveness, we were able to reproduce the correct motility modes and shape phenomenology found experimentally. We also predict the following nontrivial behavior: the direction of motion of cells can switch from parallel to perpendicular to the stripes as a function of both the adhesion strength and the width ratio of adhesive to non-adhesive stripes.
DOI:doi:10.1371/journal.pone.0064511
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0064511
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064511
 DOI: https://doi.org/10.1371/journal.pone.0064511
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Actin motors
 Actin polymerization
 Actins
 Adhesives
 Cell motility
 Deformation
 Motion
 Stiffness
K10plus-PPN:180783767X
Verknüpfungen:→ Zeitschrift

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