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Verfasst von:Swaminathan, Sumanth [VerfasserIn]   i
 Ziebert, Falko [VerfasserIn]   i
 Aranson, Igor S. [VerfasserIn]   i
 Karpeev, D. [VerfasserIn]   i
Titel:Motor-mediated microtubule self-organization in dilute and semi-dilute filament solutions
Verf.angabe:S. Swaminathan, F. Ziebert, I.S. Aranson, and D. Karpeev
Jahr:2011
Umfang:19 S.
Fussnoten:Published online 09 June 2010 ; Gesehen am 23.09.2022
Titel Quelle:Enthalten in: Mathematical modelling of natural phenomena
Ort Quelle:Les Ulis : EDP Sciences, 2006
Jahr Quelle:2011
Band/Heft Quelle:6(2011), 1, Seite 119-137
ISSN Quelle:1760-6101
Abstract:We study molecular motor-induced microtubule self-organization in dilute and semi-dilute filament solutions. In the dilute case, we use a probabilistic model of microtubule interaction via molecular motors to investigate microtubule bundle dynamics. Microtubules are modeled as polar rods interacting through fully inelastic, binary collisions. Our model indicates that initially disordered systems of interacting rods exhibit an orientational instability resulting in spontaneous ordering. We study the existence and dynamic interaction of microtubule bundles analytically and numerically. Our results reveal a long term attraction and coalescing of bundles indicating a clear coarsening in the system; microtubule bundles concentrate into fewer orientations on a slow logarithmic time scale. In semi-dilute filament solutions, multiple motors can bind a filament to several others and, for a critical motor density, induce a transition to an ordered phase with a nonzero mean orientation. Motors attach to a pair of filaments and walk along the pair bringing them into closer alignment. We develop a spatially homogenous, mean-field theory that explicitly accounts for a force-dependent detachment rate of motors, which in turn affects the mean and the fluctuations of the net force acting on a filament. We show that the transition to the oriented state can be both continuous and discontinuous when the force-dependent detachment of motors is important.
DOI:doi:10.1051/mmnp/20116106
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1051/mmnp/20116106
 Volltext: https://www.mmnp-journal.org/articles/mmnp/abs/2011/01/mmnp20106p119/mmnp20106p119.html
 DOI: https://doi.org/10.1051/mmnp/20116106
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1807841952
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