α1-adrenoceptors and takotsubo syndrome

• Verfasst von: Huang, Mengying [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Zhou, Xiao-Bo [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Titel: α1-adrenoceptors and takotsubo syndrome
• Titelzusatz: pathophysiologic connotations : authors’ reply
• Verf.angabe: Mengying Huang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin
• E-Jahr: 2021
• Jahr: July 2021
• Umfang: 1 S.
• Fussnoten: Im Titel ist die "1" bei "α1-adrenoceptors" tiefgestellt ; Gesehen am 28.06.2022
• Titel Quelle: Enthalten in: Europace
• Ort Quelle: Oxford : Oxford Univ. Press, 1999
• Jahr Quelle: 2021
• Band/Heft Quelle: 23(2021), 7, Seite 1152
• ISSN Quelle: 1532-2092
• DOI: doi:10.1093/europace/euab120
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1808293444

Abstract

We appreciate the interest of Dr Madias in our paper entitled ‘Alpha 1 adrenoceptor signaling contributes to toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes’.1We agree with Dr Madias about the illustrated points.2 Regarding receptors involved in takotsubo syndrome (TTS), we also believe that beta- and alpha-adrenoceptors must play some role in the pathogenesis of TTS. The role and mechanisms of beta-receptor activation in the toxic effect of catecholamine excess have been investigated in numerous studies using various models, including human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The contribution of beta-adrenoceptors to TTS has been well established. Although alpha-receptors in cardiomyocytes have a lower density than beta-receptors, they can also possibly contribute to TTS to a certain extent. Our paper only attempts to emphasize the role of alpha receptors in this scenario and does not underscore the importance of beta-receptors in TTS.