Age-independent first trimester screening for Down syndrome

• Verfasst von: Hörmansdörfer, Cindy [VerfasserIn]
• Verfasst von: Golatta, Michael [VerfasserIn]
• Verfasst von: Scharf, Alexander [VerfasserIn]
• Verfasst von: Hillemanns, P. [VerfasserIn]
• Verfasst von: Schmidt, P. [VerfasserIn]
• Titel: Age-independent first trimester screening for Down syndrome
• Titelzusatz: analysis of three modified software programs with 6,508 pregnancies
• Verf.angabe: C. Hörmansdörfer, M. Golatta, A. Scharf, P. Hillemanns, P. Schmidt
• Jahr: 2011
• Umfang: 6 S.
• Fussnoten: Published online: 3 April 2010 ; Gesehen am 29.06.2022
• Titel Quelle: Enthalten in: Archives of gynecology and obstetrics
• Ort Quelle: Berlin : Springer, 1870
• Jahr Quelle: 2011
• Band/Heft Quelle: 283(2011), 4, Seite 749-754
• ISSN Quelle: 1432-0711
• DOI: doi:10.1007/s00404-010-1452-y
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aneuploidy
• Sach-SW: Down syndrome
• Sach-SW: First trimester
• Sach-SW: Maternal age
• Sach-SW: Trisomy 21
• K10plus-PPN: 1808548868

Abstract

Background: The conventional first trimester screening (FTS) method integrates maternal age into risk calculation. It was suggested that this concept increases the false-positive rate in older, and the false-negative rate in younger mothers. Materials and methods: Six thousand five hundred and eight combined FTS with known fetal outcome underwent regular risk calculation with the software programs Pia fetal database (PIA) (GE-ViewPoint, GE Medical Systems), prenatal risk calculation (PRC) (Version 1.0.61, gmt/nexus), and JOY (Version 2.1, PET software). The results were mathematically modified as if generated with age-independent software (PIAmod, PRCmod, and JOYmod). Results: 17 of 40 trisomy 21 cases were present in women younger than 35. A right shift in the mean maternal age of false-negative cases occurred in all programs (PIA: 30.00, PIAmod: 32.00, PRC: 30.00, PRCmod: 32.25, JOY: 30.00, JOYmod: 34.50). The overall false-positive rate declined by −40.03% (PIAmod), −38.64% (PRCmod), and −37.50% (JOYmod) and in women over 35 (40) years by −72.37, −73.45, and −73.20% (−89.04, −90.33, and −90.56%), being then as high as in the other age groups. Conclusion: First trimester screening would become reasonable in women over 40 years. However, women over 35 would also be more often affected by false-negative results. The implications of a concept adaptation should be analyzed in a large prospective study.