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| Verfasst von: | Kantarcioglu, Bulent [VerfasserIn]  |
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| | Darki, Amir [VerfasserIn] |
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| | Siddiqui, Fakiha [VerfasserIn] |
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| | Hoppensteadt, Debra [VerfasserIn] |
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| | Lewis, Joseph [VerfasserIn] |
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| | Krämer, Roland [VerfasserIn] |
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| | Adiguzel, Cafer [VerfasserIn] |
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| | Fareed, Jawed [VerfasserIn] |
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| Titel: | The relevance of anti-pf4 antibody isotypes and endogenous glycosaminoglycans and their relationship with inflammatory biomarkers in pulmonary embolism patients |
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| Verf.angabe: | Bulent Kantarcioglu, Amir Darki, Fakiha Siddiqui, Debra Hoppensteadt, Joseph Lewis, Roland Krämer, Cafer Adiguzel, Jawed Fareed |
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| E-Jahr: | 2022 |
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| Jahr: | March 31, 2022 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 29.06.2022 |
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| Titel Quelle: | Enthalten in: Clinical and applied thrombosis, hemostasis |
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| Ort Quelle: | Thousand Oaks, Calif. : Sage, 1995 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 28(2022), Artikel-ID 10760296221091770, Seite 1-12 |
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| ISSN Quelle: | 1938-2723 |
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| Abstract: | IntroductionPrevious studies have shown that inflammation may contribute to the interplay of endogenous glycosaminoglycans (GAGs) and anti-PF4 antibodies. In this study, we quantified the levels of anti-PF4 antibody isotypes and endogenous GAGs together with inflammatory biomarkers in pulmonary embolism (PE) patients to determine whether there is a relationship in between. Identification of this relationship may provide insight to the complex pathophysiology of PE and HIT and may also be useful for development of potential prognostic, diagnostic and therapeutic interventions.Materials and MethodsPlasma samples from PE patients (n: 210) were analyzed for anti-PF4 antibody isotypes and various thrombo-inflammatory cytokines utilizing commercially available biochip array and ELISA methods. The endogenous GAG levels in PE patients? plasma were quantified using a fluorescence quenching method. The collected data analyzed to demonstrate the relationship between various parameters.ResultsThe endogenous GAG levels were increased in the PE group (P? |
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| DOI: | doi:10.1177/10760296221091770 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1177/10760296221091770 |
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| | DOI: https://doi.org/10.1177/10760296221091770 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1808551400 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ relevance of anti-pf4 antibody isotypes and endogenous glycosaminoglycans and their relationship with inflammatory biomarkers in pulmonary embolism patients / Kantarcioglu, Bulent [VerfasserIn]; March 31, 2022 (Online-Ressource)
