| |  Online-Ressource |
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| Verfasst von: | Beck, Grietje [VerfasserIn]  |
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| | Yard, Benito A. [VerfasserIn] |
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| | Schulte, Jutta [VerfasserIn] |
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| | Oberacker, Ralph [VerfasserIn] |
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| | Ackern, Klaus van [VerfasserIn] |
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| | Woude, Fokko J. van der [VerfasserIn] |
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| | Krimsky, M [VerfasserIn] |
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| | Kaszkin, M [VerfasserIn] |
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| | Yedgar, S [VerfasserIn] |
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| Titel: | Inhibition of LPS-induced chemokine production in human lung endothelial cells by lipid conjugates anchored to the membrane |
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| Verf.angabe: | G Ch Beck, B A Yard, J Schulte, R Oberacker, K van Ackern, F J van der Woude, M Krimsky, M Kaszkin & S Yedgar |
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| Jahr: | 2002 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 29.06.2022 |
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| Titel Quelle: | Enthalten in: British journal of pharmacology |
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| Ort Quelle: | Malden, MA : Wiley, 1946 |
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| Jahr Quelle: | 2002 |
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| Band/Heft Quelle: | 135(2002), 7, Seite 1665-1674 |
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| ISSN Quelle: | 1476-5381 |
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| Abstract: | In acute respiratory distress syndrome (ARDS) induced by endotoxins, a high production of inflammatory mediators by microvascular lung endothelial cells (LMVEC) can be observed. Activation of cells by endotoxins may result in elevated secretion of phospholipase A2 (sPLA2) which is thought to contribute to tissue damage. The present study was undertaken to investigate the role of sPLA2 in chemokine production in human lung microvascular endothelial cells (LMVEC) stimulated with the endotoxins lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In particular, we investigated the effects of sPLA2 inhibitors, specifically, the extracellular PLA2 inhibitors (ExPLIs), composed of N-derivatized phosphatidyl-ethanolamine linked to polymeric carriers, and LY311727, a specific inhibitor of non-pancreatic sPLA2. |
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| DOI: | doi:10.1038/sj.bjp.0704618 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://dx.doi.org/10.1038/sj.bjp.0704618 |
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| | Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573284/ |
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| | DOI: https://doi.org/10.1038/sj.bjp.0704618 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1808553446 |
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| Verknüpfungen: | → Zeitschrift |
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Inhibition of LPS-induced chemokine production in human lung endothelial cells by lipid conjugates anchored to the membrane / Beck, Grietje [VerfasserIn]; 2002 (Online-Ressource)
