| |  Online-Ressource |
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| Verfasst von: | Schoop, Valentin [VerfasserIn]  |
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| | Martello, Andrea [VerfasserIn] |
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| | Eden, Emily R. [VerfasserIn] |
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| | Höglinger, Doris [VerfasserIn] |
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| Titel: | Cellular cholesterol and how to find it [symbol star] |
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| Verf.angabe: | Valentin Schoop, Andrea Martello, Emily R. Eden, Doris Höglinger |
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| E-Jahr: | 2021 |
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| Jahr: | 10 June 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 30.06.2022 ; Im Titel ist "☆" hochgestellt |
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| Titel Quelle: | Enthalten in: Biochimica et biophysica acta / Molecular and cell biology of lipids |
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| Ort Quelle: | Amsterdam : Elsevier, 1998 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 1866(2021), 9, Artikel-ID 158989, Seite 1-12 |
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| ISSN Quelle: | 1879-2618 |
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| Abstract: | Cholesterol is an essential component of eukaryotic cellular membranes. Information about its subcellular localization and transport pathways inside cells are key for the understanding and treatment of cholesterol-related diseases. In this review we give an overview over the most commonly used methods that contributed to our current understanding of subcellular cholesterol localization and transport routes. First, we discuss methods that provide insights into cholesterol metabolism based on readouts of downstream effects such as esterification. Subsequently, we focus on the use of cholesterol-binding molecules as probes that facilitate visualization and quantification of sterols inside of cells. Finally, we explore different analogues of cholesterol which, when taken up by living cells, are integrated and transported in a similar fashion as endogenous sterols. Taken together, we highlight the challenges and advantages of each method such that researchers studying aspects of cholesterol transport may choose the most pertinent approach for their problem. |
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| DOI: | doi:10.1016/j.bbalip.2021.158989 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.bbalip.2021.158989 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1388198121001177 |
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| | DOI: https://doi.org/10.1016/j.bbalip.2021.158989 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cholesterol analogues |
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| | Fluorescence microscopy |
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| | Intracellular trafficking |
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| | Lipid transport |
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| | Organelle contact sites |
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| K10plus-PPN: | 1808673522 |
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| Verknüpfungen: | → Zeitschrift |
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Cellular cholesterol and how to find it [symbol star] / Schoop, Valentin [VerfasserIn]; 10 June 2021 (Online-Ressource)
