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Verfasst von:Schwender, Stefan [VerfasserIn]   i
 Hein, Andreas [VerfasserIn]   i
 Imrich, Horst [VerfasserIn]   i
 Czub, Stefanie [VerfasserIn]   i
 Dörries, Rüdiger [VerfasserIn]   i
Titel:Modulation of acute coronavirus-induced encephalomyelitis in γ-irradiated rats by transfer of naive lymphocyte subsets before infection
Verf.angabe:Stefan Schwender, Andreas Hein, Horst Imrich, Stefanie Czub and Rüdiger Dörries
Jahr:1999
Umfang:9 S.
Fussnoten:Elektronische Reproduktion der Druck-Ausgabe ; Published online: 10 Jul 2009 ; Gesehen am 30.06.2022
Titel Quelle:Enthalten in: Journal of neurovirology
Ort Quelle:New York, NY : Springer, 1995
Jahr Quelle:1999
Band/Heft Quelle:5(1999), 3, Seite 249-257
ISSN Quelle:1538-2443
Abstract:Clinical course, recovery of infectious virus from brain tissue and histopathology of the central nervous system were examined in γ-irradiated Lewis rats reconstituted by naive lymphocytes before infection with coronavirus MHV-4 (strain JHM). Up to 9 days past infection, no differences were seen between immunologically competent and immuno-deficient animals in terms of onset and progression of neurological disease. However, in the latter animals neurological symptoms were dominated by signs of encephalitis instead of paralytic disease as usually seen in immunocompetent animals. Nevertheless, despite high titers of infectious virus in the CNS of immunodeficient animals only mild histopathological changes were noticeable. In contrast, infectious virus in the CNS of immunologically competent animals was below the detection limit of the assay. Paralytic disease and tissue destruction were T lymphocyte mediated because γ-irradiated rats that were reconstituted by CD4+ or CD8+ T lymphocyte enriched cells in the absence of B lymphocytes revealed an earlier onset of clinical symptoms and a more rapid deterioration of their clinical state compared to fully competent animals. Whereas in CD4+ T cell reconsituted animals infectious virus was moderately reduced and tissue destruction as well as inflammatory changes in the CNS were focal, in CD8+ T cell reconstituted animals vacuolizing white matter inflammation was diffuse without reduction of infectious virus in brain tissue. From the presented data we conclude that in the acute stage of JHMV-induced encephalomyelitis of Lewis rats: (i) tissue destruction and paralytic clinical symptomatology are mainly T cell-mediated; (ii) CD4+ T lymphocytes can directly contribute to reduction of viral load in the brain and (iii) only coordinated action of both, the T and the B cell compartment enables animals to survive the infection and recover from disease.
DOI:doi:10.3109/13550289909015811
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3109/13550289909015811
 Volltext: https://www.tandfonline.com/doi/abs/10.3109/13550289909015811
 Volltext: https://www.jneurovirol.com/pdf/5(3)/249-257.pdf
 DOI: https://doi.org/10.3109/13550289909015811
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:central nervous system
 coronavirus
 encephalomyelitis
 lymphocyte subsets
K10plus-PPN:1808676319
Verknüpfungen:→ Zeitschrift

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