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Verfasst von:Illanes, Sergio [VerfasserIn]   i
 Liesz, Arthur [VerfasserIn]   i
 Sun, Li [VerfasserIn]   i
 Dalpke, Alexander [VerfasserIn]   i
 Zorn, Markus [VerfasserIn]   i
 Veltkamp, Roland [VerfasserIn]   i
Titel:Hematoma size as major modulator of the cellular immune system after experimental intracerebral hemorrhage
Verf.angabe:Sergio Illanes, Arthur Liesz, Li Sun, Alexander Dalpke, Markus Zorn, Roland Veltkamp
Jahr:2011
Umfang:5 S.
Fussnoten:Available online 3 December 2010 ; Gesehen am 01.07.2022
Titel Quelle:Enthalten in: Neuroscience letters
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2011
Band/Heft Quelle:490(2011), 3, Seite 170-174
ISSN Quelle:1872-7972
Abstract:Inflammatory cascades are increasingly recognized as an important pathophysiological mechanism in intracerebral hemorrhage (ICH). In contrast, the effect of ICH on the systemic immune system has barely been investigated. We examined the effects of different hematoma volumes on immune cell subpopulations in experimental murine ICH. In C57BL/6 mice, ICH was induced by striatal injection of autologous blood (10, 30 or 50μL). Control animals received the respective sham operation. Three days after ICH induction, differential blood leukocyte counting was performed. Lymphocyte subpopulations were further characterized by flow cytometry in blood, spleen, lymph node and thymus. Infectious complications were studied using microbiological cultures of blood and lungs. Only after large ICH a marked decrease of leukocyte counts and most lymphocyte subsets was observed in all organs. Despite this general leukocytopenia, a significant, up to 10-fold increase, was detected in the monocyte population after extensive hemorrhage. After moderate ICH induction, only specific lymphocyte subpopulations were differentially affected. Mature thymic cells were unaffected while immature CD4+CD8+ cells were depleted by over 90% after large ICH. A significant proportion of mice with extensive ICH (36.4%) developed spontaneous pneumonia and/or bacteremia while none of the sham operated mice had infectious complications. The ICH size determines the extent of systemic immunomodulation. Large ICH predisposes animals to infections.
DOI:doi:10.1016/j.neulet.2010.11.065
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.neulet.2010.11.065
 Volltext: https://www.sciencedirect.com/science/article/pii/S0304394010015193
 DOI: https://doi.org/10.1016/j.neulet.2010.11.065
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Experimental Stroke
 Intracerebral hemorrhage
 Post stroke immunosupression
K10plus-PPN:1808784138
Verknüpfungen:→ Zeitschrift

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