| |  Online-Ressource |
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| Verfasst von: | Tiede, Christoph [VerfasserIn]  |
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| | Chiriac, Ute [VerfasserIn] |
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| | Dubinski, Daniel [VerfasserIn] |
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| | Raimann, Florian J. [VerfasserIn] |
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| | Frey, Otto R. [VerfasserIn] |
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| | Röhr, Anka C. [VerfasserIn] |
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| | Wieduwilt, Anna [VerfasserIn] |
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| | Eibach, Michael [VerfasserIn] |
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| | Filmann, Natalie [VerfasserIn] |
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| | Senft, Christian [VerfasserIn] |
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| | Zacharowski, Kai [VerfasserIn] |
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| | Seifert, Volker [VerfasserIn] |
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| | Mersmann, Jan [VerfasserIn] |
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| Titel: | Cerebrospinal fluid concentrations of meropenem and vancomycin in ventriculitis patients obtained by TDM-guided continuous infusion |
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| Verf.angabe: | Christoph Tiede, Ute Chiriac, Daniel Dubinski, Florian J. Raimann, Otto R. Frey, Anka C. Röhr, Anna Wieduwilt, Michael Eibach, Natalie Filmann, Christian Senft, Kai Zacharowski, Volker Seifert and Jan Mersmann |
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| E-Jahr: | 2021 |
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| Jahr: | 20 November 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 01.07.2022 ; This article belongs to the Special Issue TDM, Individual Dosing and Application of Antibiotics/Antiinfectives in Critically Ill Patients |
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| Titel Quelle: | Enthalten in: Antibiotics |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 10(2021), 11, Artikel-ID 1421, Seite 1-11 |
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| ISSN Quelle: | 2079-6382 |
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| Abstract: | Effective antibiotic therapy of cerebral infections such as meningitis or ventriculitis is hindered by low penetration into the cerebrospinal fluid (CSF). Because continuous infusion of meropenem and vancomycin and routine therapeutic drug monitoring (TDM) have been proposed to optimize antimicrobial exposure in ventriculitis patients, an individualized dosing strategy was implemented in our department. We present a retrospective analysis of meropenem and vancomycin concentrations in serum and CSF in the first nine ventriculitis patients treated with continuous infusion and TDM-guided dose optimization aiming at 20-30 mg/L. Median initial dosing was 8.8 g/24 h meropenem and 4.25 g/24 h vancomycin, respectively, resulting in median serum concentrations of 21.3 mg/L for meropenem and 24.5 mg/L for vancomycin and CSF concentrations of 3.4 mg/L for meropenem and 1.7 mg/L for vancomycin. Median CSF penetration was 15% for meropenem and 7% for vancomycin. With initial dosing, all but one patient achieved CSF concentrations above 1 mg/L. Dose adjustment according to TDM ensured sufficient CSF concentrations in all patients within 48 h of treatment. Given the limited penetration, continuous infusion of meropenem and vancomycin based on renal function and TDM-guided dose optimization appears a reasonable approach to attain sufficient CSF concentrations in ventriculitis patients. |
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| DOI: | doi:10.3390/antibiotics10111421 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: https://doi.org/10.3390/antibiotics10111421 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2079-6382/10/11/1421 |
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| | DOI: https://doi.org/10.3390/antibiotics10111421 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cerebrospinal fluid |
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| | critical care |
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| | meropenem |
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| | pharmacokinetics |
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| | therapeutic drug monitoring |
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| | vancomycin |
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| | ventriculitis |
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| K10plus-PPN: | 1808787773 |
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| Verknüpfungen: | → Zeitschrift |
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Cerebrospinal fluid concentrations of meropenem and vancomycin in ventriculitis patients obtained by TDM-guided continuous infusion / Tiede, Christoph [VerfasserIn]; 20 November 2021 (Online-Ressource)
