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Verfasst von:Jaffe, Allan S. [VerfasserIn]   i
 Lindahl, Bertil [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
Titel:Sensitive troponin I assay in patients with suspected acute coronary syndrome
Verf.angabe:Allan S. Jaffe, Bertil Lindahl, Hugo A. Katus
E-Jahr:2011
Jahr:August 3, 2011
Umfang:2 S.
Fussnoten:Gesehen am 04.07.2022
Titel Quelle:Enthalten in: American Medical AssociationThe journal of the American Medical Association
Ort Quelle:Chicago, Ill. : American Medical Association, 1883
Jahr Quelle:2011
Band/Heft Quelle:306(2011), 5, Seite 488-489
ISSN Quelle:1538-3598
Abstract:To the Editor: The study on the use of a contemporary sensitive troponin assay and its association with reductions in death and recurrent MI used a diagnostic threshold of troponin of 0.05 ng/mL, based on a coefficient of variation (CV) of less than 10% at that level. However, the 99th percentile reference value of 0.012 ng/mL would have been preferable as the diagnostic threshold because this is the value recommended by guidelines groups. This cutoff value optimizes the identification of patients at risk with ACS in all studies that have explored this issue. There are many reasons for the reluctance of clinicians to use the 99th percentile value, but one reason often cited is that the assay does not have imprecision less than 10% at that value. The Biochemistry Group of the Global Task Force for the Universal Definition of Acute Myocardial Infarction and the Global Task Force itself have for years advocated for this level of imprecision at the 99th percentile value but have never suggested using a less sensitive value when this level of imprecision is not met because the 99th percentile value maximizes clinical outcomes. In addition, modest increases in imprecision do not cause false-positive values whether used for diagnosis or prognosis. However, increased imprecision can affect the ability to observe serial changes.
DOI:doi:10.1001/jama.2011.1062
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1001/jama.2011.1062
 DOI: https://doi.org/10.1001/jama.2011.1062
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1809031311
Verknüpfungen:→ Zeitschrift

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