Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders

• Verfasst von: Jarius, Sven [VerfasserIn]
• Verfasst von: Jacobi, Christian [VerfasserIn]
• Verfasst von: de Seze, Jerome [VerfasserIn]
• Verfasst von: Zephir, Helene [VerfasserIn]
• Verfasst von: Paul, Friedemann [VerfasserIn]
• Verfasst von: Franciotta, Diego [VerfasserIn]
• Verfasst von: Rommer, Paulus [VerfasserIn]
• Verfasst von: Mader, Simone [VerfasserIn]
• Verfasst von: Kleiter, Ingo [VerfasserIn]
• Verfasst von: Reindl, Markus [VerfasserIn]
• Verfasst von: Akman-Demir, Gulsen [VerfasserIn]
• Verfasst von: Seifert-Held, Thomas [VerfasserIn]
• Verfasst von: Kristoferitsch, Wolfgang [VerfasserIn]
• Verfasst von: Melms, Arthur [VerfasserIn]
• Verfasst von: Wandinger, Klaus-Peter [VerfasserIn]
• Verfasst von: Wildemann, Brigitte [VerfasserIn]
• Titel: Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders
• Verf.angabe: Sven Jarius, Christian Jacobi, Jerome de Seze, Helene Zephir, Friedemann Paul, Diego Franciotta, Paulus Rommer, Simone Mader, Ingo Kleiter, Markus Reindl, Gulsen Akman-Demir, Thomas Seifert-Held, Wolfgang Kristoferitsch, Arthur Melms, Klaus-Peter Wandinger and Brigitte Wildemann
• E-Jahr: 2011
• Jahr: May 4, 2011
• Umfang: 7 S.
• Fussnoten: Gesehen am 04.07.2022
• Titel Quelle: Enthalten in: Multiple sclerosis journal
• Ort Quelle: London : Sage, 1995
• Jahr Quelle: 2011
• Band/Heft Quelle: 17(2011), 9, Seite 1067-1073
• ISSN Quelle: 1477-0970
• DOI: doi:10.1177/1352458511403958
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: antibody to aquaporin-4
• Sach-SW: connective tissue disorders
• Sach-SW: diagnosis
• Sach-SW: longitudinally extensive transverse myelitis
• Sach-SW: neuromyelitis optica (Devic’s disease)
• Sach-SW: neuropsychiatric lupus
• Sach-SW: NMO-IgG
• Sach-SW: rheumatic diseases
• Sach-SW: scleroderma
• Sach-SW: Sjögren’s syndrome
• Sach-SW: systemic lupus erythematosus
• Sach-SW: vasculitis
• K10plus-PPN: 1809051525

Abstract

Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) and recurrent optic neuritis (rON). However, AQP4-Ab has been found also in patients with co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) or Sjögren’s syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation., Objectives: In this study, we aimed at evaluating the syndrome specificity and frequency of AQP4-Ab in patients with rheumatic diseases and neurological symptoms., Methods: For this purpose, serum samples from 109 neurological patients with established connective tissue disorders (CTD) (n = 54), possible CTD (n = 42), or vasculitis (n = 13) were analysed for the presence of AQP4-Ab by a cell-based assay employing recombinant human AQP4., Results: AQP4-Ab was detectable in 31/40 (78%) patients with CTD and NMO spectrum disorders (median titre, 1:1000) but in none of the samples obtained from patients with CTD or vasculitis and neurological disorders other than NMO, LETM, or rON (n = 69)., Conclusion: The high syndrome specificity of the antibody for neuromyelitis optica spectrum disorders (NMOSDs) in patients with CTD supports the concept of AQP4-Ab being involved in the pathogenesis of these neurological conditions, and argues against AQP4-Ab simply being part of the polyclonal B cell activation generally associated with rheumatic diseases. Moreover, the finding that AQP4-Ab is present in patients with CTD and co-existing NMOSD with approximately the same frequency as in patients without CTD strengthens the case of CTD and AQP4-Ab positive NMOSD representing two co-existing yet distinct entities in the majority of patients.