Novel roles for hERG K+ channels in cell proliferation and apoptosis

• Verfasst von: Jehle, Julian [VerfasserIn]
• Verfasst von: Schweizer, Patrick Alexander [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Thomas, Dierk [VerfasserIn]
• Titel: Novel roles for hERG K+ channels in cell proliferation and apoptosis
• Verf.angabe: J. Jehle, P.A. Schweizer, H.A. Katus and D. Thomas
• E-Jahr: 2011
• Jahr: 18 August 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 05.07.2022 ; Im Titel ist das Pluszeichen hochgestellt
• Titel Quelle: Enthalten in: Cell death & disease
• Ort Quelle: London [u.a.] : Nature Publishing Group, 2010
• Jahr Quelle: 2011
• Band/Heft Quelle: 2(2011), 8, Artikel-ID e193, Seite 1-8
• ISSN Quelle: 2041-4889
• DOI: doi:10.1038/cddis.2011.77
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Apoptosis
• Sach-SW: Cancer therapy
• Sach-SW: Cell proliferation
• Sach-SW: Potassium channels
• K10plus-PPN: 1809108624

Abstract

The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K+ channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K+ channels as future drug target in anticancer therapy is highlighted.