| |  Online-Ressource |
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| Verfasst von: | Jöckel, Lars Thomas [VerfasserIn]  |
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| | Wallich, Reinhard [VerfasserIn] |
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| | Martin, P. [VerfasserIn] |
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| | Sanchez-Martinez, D. [VerfasserIn] |
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| | Weber, F. C. [VerfasserIn] |
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| | Martin, S. F. [VerfasserIn] |
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| | Borner, C. [VerfasserIn] |
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| | Pardo, J. [VerfasserIn] |
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| | Froelich, C. [VerfasserIn] |
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| | Simon, M. M. [VerfasserIn] |
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| Titel: | Mouse granzyme K has pro-inflammatory potential |
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| Verf.angabe: | L.T. Joeckel, R. Wallich, P. Martin, D. Sanchez-Martinez, F.C. Weber, S.F. Martin, C. Borner, J. Pardo, C. Froelich and M.M. Simon |
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| E-Jahr: | 2011 |
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| Jahr: | 11 February 2011 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 05.07.2022 |
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| Titel Quelle: | Enthalten in: Cell death and differentiation |
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| Ort Quelle: | Houndmills, Basingstoke : Nature Publishing Group, 1997 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 18(2011), 7, Seite 1112-1119 |
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| ISSN Quelle: | 1476-5403 |
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| Abstract: | Granzymes (gzms) are key components of T-killer (Tc) cells believed to mediate pro-apoptotic activities. Recent evidence suggests that gzms also possess non-cytotoxic activities that contribute to host defense. In this study, we show that Tc cells from lymphocytic choriomeningitis virus (LCMV)-infected wild-type (wt) and gzm A/B-deficient mice express similar levels of gzmK protein, with both mouse strains efficiently controlling infection. GzmK, in recombinant form or secreted by ex vivo-derived LCMV-immune gzmAxB−/− Tc cells, lacks pro-apoptotic activity. Instead, gzmK induces primary mouse macrophages to process and secrete interleukin-1β, independent of the ATP receptor P2X7. Together with the finding that IL-1Ra (Anakinra) treatment inhibits virus elimination but not generation of cytotoxic Tc cells in wt mice, the data suggest that Tc cells control LCMV through non-cytotoxic processes that involve gzmK. |
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| DOI: | doi:10.1038/cdd.2011.5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/cdd.2011.5 |
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| | Volltext: https://www.nature.com/articles/cdd20115 |
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| | DOI: https://doi.org/10.1038/cdd.2011.5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cytotoxic T cells |
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| | Enzymes |
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| | Viral infection |
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| K10plus-PPN: | 1809129109 |
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| Verknüpfungen: | → Zeitschrift |
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Mouse granzyme K has pro-inflammatory potential / Jöckel, Lars Thomas [VerfasserIn]; 11 February 2011 (Online-Ressource)
