| |  Online-Ressource |
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| Verfasst von: | Jungraithmayr, Therese [VerfasserIn]  |
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| | Hofer, Katrin [VerfasserIn] |
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| | Cochat, Pierre [VerfasserIn] |
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| | Chernin, Gil [VerfasserIn] |
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| | Cortina, Gerard [VerfasserIn] |
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| | Fargue, Sonja [VerfasserIn] |
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| | Grimm, Paul [VerfasserIn] |
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| | Knüppel, Tanja [VerfasserIn] |
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| | Kowarsch, Andreas [VerfasserIn] |
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| | Neuhaus, Thomas [VerfasserIn] |
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| | Pagel, Philipp [VerfasserIn] |
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| | Pfeiffer, Karl P. [VerfasserIn] |
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| | Schaefer, Franz [VerfasserIn] |
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| | Schönermarck, Ulf [VerfasserIn] |
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| | Seeman, Tomas [VerfasserIn] |
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| | Tönshoff, Burkhard [VerfasserIn] |
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| | Weber, Stefanie [VerfasserIn] |
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| | Winn, Michelle P. [VerfasserIn] |
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| | Zschocke, Johannes [VerfasserIn] |
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| | Zimmerhackl, Lothar B. [VerfasserIn] |
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| Titel: | Screening for NPHS2 mutations may help predict FSGS recurrence after transplantation |
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| Verf.angabe: | Therese C. Jungraithmayr, Katrin Hofer, Pierre Cochat, Gil Chernin, Gerard Cortina, Sonja Fargue, Paul Grimm, Tanja Knueppel, Andreas Kowarsch, Thomas Neuhaus, Philipp Pagel, Karl P. Pfeiffer, Franz Schäfer, Ulf Schönermarck, Tomas Seeman, Burkhard Toenshoff, Stefanie Weber, Michelle P. Winn, Johannes Zschocke, and Lothar B. Zimmerhackl |
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| E-Jahr: | 2011 |
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| Jahr: | March 3, 2011 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 06.07.2022 |
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| Titel Quelle: | Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology |
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| Ort Quelle: | Washington, DC : American Society of Nephrology, 1990 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 22(2011), 3, Seite 579-585 |
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| ISSN Quelle: | 1533-3450 |
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| Abstract: | Steroid-resistant focal segmental glomerulosclerosis (FSGS) often recurs after renal transplantation. In this international survey, we sought to identify genotype-phenotype correlations of recurrent FSGS. We surveyed 83 patients with childhood-onset primary FSGS who received at least one renal allograft and analyzed 53 of these patients for NPHS2 mutations. The mean age at diagnosis was 6.7 years, and the mean age at first renal transplantation was 13 years. FSGS recurred in 30 patients (36%) after a median of 13 days (range, 1.5 to 152 days). Twenty-three patients received a second kidney transplant, and FSGS recurred in 11 (48%) after a median of 16 days (range, 2.7 to 66 days). None of the 11 patients with homozygous or compound heterozygous NPHS2 mutations developed recurrent FSGS compared with 45% of patients without mutations. These data suggest that genetic testing for pathogenic mutations may be important for prognosis and treatment of FSGS both before and after transplantation. |
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| DOI: | doi:10.1681/ASN.2010010029 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1681/ASN.2010010029 |
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| | Volltext: https://jasn.asnjournals.org/content/22/3/579 |
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| | DOI: https://doi.org/10.1681/ASN.2010010029 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1809281202 |
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| Verknüpfungen: | → Zeitschrift |
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Screening for NPHS2 mutations may help predict FSGS recurrence after transplantation / Jungraithmayr, Therese [VerfasserIn]; March 3, 2011 (Online-Ressource)
