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Verfasst von:Bühler, Louisa [VerfasserIn]   i
 Enderle, Markus D. [VerfasserIn]   i
 Kahn, Nicolas [VerfasserIn]   i
 Polke, Markus [VerfasserIn]   i
 Schneider, Marc [VerfasserIn]   i
 Heußel, Claus Peter [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Linzenbold, Walter [VerfasserIn]   i
Titel:Establishment of a tissue-mimicking surrogate for pulmonary lesions to improve the development of RFA instruments and algorithms
Verf.angabe:Louisa Bühler, Markus D. Enderle, Nicolas Kahn, Markus Polke, Marc A. Schneider, Claus Peter Heußel, Felix J.F. Herth and Walter Linzenbold
E-Jahr:2022
Jahr:10 May 2022
Umfang:10 S.
Fussnoten:Gesehen am 06.07.2022 ; This article belongs to the special issue "Clinical application for tissue engineering"
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2022
Band/Heft Quelle:10(2022), 5, special issue, Artikel-ID 1100, Seite 1-10
ISSN Quelle:2227-9059
Abstract:(1) Development of radiofrequency ablation (RFA) systems for pulmonary lesions is restricted by availability of human tumor specimens and limited comparability of animal tissue. We aimed to develop a new surrogate tissue overcoming these drawbacks. (2) Reference values for electrical impedance in lung tumor tissue were collected during routine lung tumor RFA (n = 10). Subsequently, a tissue-mimicking surrogate with comparable electrical impedance and facilitating detection of the ablation margins was developed. (3) The mean electrical impedance for all patients was 103.5 ± 14.7 Ω. In the optimized surrogate tissue model consisting of 68% agar solution, 23% egg yolk, 9% thermochromic ink, and variable amounts of sodium chloride, the mean electrical impedance was adjustable from 74.3 ± 0.4 Ω to 183.2 ± 5.6 Ω and was a function (y = 368.4x + 175.2; R2 = 0.96; p < 0.001) of sodium chloride concentration (between 0 and 0.3%). The surrogate tissue achieved sufficient dimensional stability, and sample cuts revealed clear margins of color change for temperatures higher 60 °C. (4) The tissue-mimicking surrogate can be adapted to lung tumor with respect to its electrical properties. As the surrogate tissue allows for simple and cost-effective manufacturing, it is suitable for extensive laboratory testing of RFA systems for pulmonary ablation.
DOI:doi:10.3390/biomedicines10051100
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/biomedicines10051100
 Volltext: https://www.mdpi.com/2227-9059/10/5/1100
 DOI: https://doi.org/10.3390/biomedicines10051100
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:agar
 electrical impedance
 lung cancer
 pulmonary lesions
 radiofrequency ablation
 thermochromic
 tissue-mimicking phantom
K10plus-PPN:1809297427
Verknüpfungen:→ Zeitschrift

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