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| Verfasst von: | Bühler, Louisa [VerfasserIn]  |
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| | Enderle, Markus D. [VerfasserIn] |
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| | Kahn, Nicolas [VerfasserIn] |
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| | Polke, Markus [VerfasserIn] |
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| | Schneider, Marc [VerfasserIn] |
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| | Heußel, Claus Peter [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Linzenbold, Walter [VerfasserIn] |
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| Titel: | Establishment of a tissue-mimicking surrogate for pulmonary lesions to improve the development of RFA instruments and algorithms |
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| Verf.angabe: | Louisa Bühler, Markus D. Enderle, Nicolas Kahn, Markus Polke, Marc A. Schneider, Claus Peter Heußel, Felix J.F. Herth and Walter Linzenbold |
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| E-Jahr: | 2022 |
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| Jahr: | 10 May 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 06.07.2022 ; This article belongs to the special issue "Clinical application for tissue engineering" |
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| Titel Quelle: | Enthalten in: Biomedicines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 10(2022), 5, special issue, Artikel-ID 1100, Seite 1-10 |
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| ISSN Quelle: | 2227-9059 |
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| Abstract: | (1) Development of radiofrequency ablation (RFA) systems for pulmonary lesions is restricted by availability of human tumor specimens and limited comparability of animal tissue. We aimed to develop a new surrogate tissue overcoming these drawbacks. (2) Reference values for electrical impedance in lung tumor tissue were collected during routine lung tumor RFA (n = 10). Subsequently, a tissue-mimicking surrogate with comparable electrical impedance and facilitating detection of the ablation margins was developed. (3) The mean electrical impedance for all patients was 103.5 ± 14.7 Ω. In the optimized surrogate tissue model consisting of 68% agar solution, 23% egg yolk, 9% thermochromic ink, and variable amounts of sodium chloride, the mean electrical impedance was adjustable from 74.3 ± 0.4 Ω to 183.2 ± 5.6 Ω and was a function (y = 368.4x + 175.2; R2 = 0.96; p < 0.001) of sodium chloride concentration (between 0 and 0.3%). The surrogate tissue achieved sufficient dimensional stability, and sample cuts revealed clear margins of color change for temperatures higher 60 °C. (4) The tissue-mimicking surrogate can be adapted to lung tumor with respect to its electrical properties. As the surrogate tissue allows for simple and cost-effective manufacturing, it is suitable for extensive laboratory testing of RFA systems for pulmonary ablation. |
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| DOI: | doi:10.3390/biomedicines10051100 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/biomedicines10051100 |
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| | Volltext: https://www.mdpi.com/2227-9059/10/5/1100 |
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| | DOI: https://doi.org/10.3390/biomedicines10051100 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | agar |
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| | electrical impedance |
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| | lung cancer |
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| | pulmonary lesions |
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| | radiofrequency ablation |
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| | thermochromic |
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| | tissue-mimicking phantom |
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| K10plus-PPN: | 1809297427 |
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| Verknüpfungen: | → Zeitschrift |
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Establishment of a tissue-mimicking surrogate for pulmonary lesions to improve the development of RFA instruments and algorithms / Bühler, Louisa [VerfasserIn]; 10 May 2022 (Online-Ressource)
