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Status: Bibliographieeintrag

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Verfasst von:Boccuni, Isabella [VerfasserIn]   i
 Fairless, Richard [VerfasserIn]   i
Titel:Retinal glutamate neurotransmission
Titelzusatz:from physiology to pathophysiological mechanisms of retinal ganglion cell degeneration
Verf.angabe:Isabella Boccuni and Richard Fairless
E-Jahr:2022
Jahr:25 April 2022
Umfang:33 S.
Fussnoten:Gesehen am 07.07.2022 ; This article belongs to the special issue "New insights on cellular biology of retinal degenerations"
Titel Quelle:Enthalten in: Life
Ort Quelle:Basel : MDPI, 2011
Jahr Quelle:2022
Band/Heft Quelle:12(2022), 5, special issue, Artikel-ID 638, Seite 1-33
ISSN Quelle:2075-1729
Abstract:Glutamate neurotransmission and metabolism are finely modulated by the retinal network, where the efficient processing of visual information is shaped by the differential distribution and composition of glutamate receptors and transporters. However, disturbances in glutamate homeostasis can result in glutamate excitotoxicity, a major initiating factor of common neurodegenerative diseases. Within the retina, glutamate excitotoxicity can impair visual transmission by initiating degeneration of neuronal populations, including retinal ganglion cells (RGCs). The vulnerability of RGCs is observed not just as a result of retinal diseases but has also been ascribed to other common neurodegenerative and peripheral diseases. In this review, we describe the vulnerability of RGCs to glutamate excitotoxicity and the contribution of different glutamate receptors and transporters to this. In particular, we focus on the N-methyl-d-aspartate (NMDA) receptor as the major effector of glutamate-induced mechanisms of neurodegeneration, including impairment of calcium homeostasis, changes in gene expression and signalling, and mitochondrial dysfunction, as well as the role of endoplasmic reticular stress. Due to recent developments in the search for modulators of NMDA receptor signalling, novel neuroprotective strategies may be on the horizon.
DOI:doi:10.3390/life12050638
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/life12050638
 Volltext: https://www.mdpi.com/2075-1729/12/5/638
 DOI: https://doi.org/10.3390/life12050638
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:excitotoxicity
 glutamate
 neuronal vulnerability
 NMDA receptor
 retina
 retinal ganglion cell
K10plus-PPN:1809445582
Verknüpfungen:→ Zeitschrift

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