Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kamrath, Clemens [VerfasserIn]  |
| Böhles, Hansjosef [VerfasserIn]  |
| Maser-Gluth, Christiane [VerfasserIn]  |
Titel: | Comparison of two different radioimmunoassays to measure 17-hydroxyprogesterone during treatment monitoring of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency |
Verf.angabe: | Clemens Kamrath, Hansjosef Böhles, Christiane Maser-Gluth |
Jahr: | 2011 |
Umfang: | 4 S. |
Fussnoten: | Available online 8 October 2010 ; Gesehen am 07.07.2022 |
Titel Quelle: | Enthalten in: Clinica chimica acta |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1956 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 412(2011), 1/2, Seite 186-189 |
ISSN Quelle: | 1873-3492 |
Abstract: | Background - Accurate measurement of 17-hydroxyprogesterone (17-OHP) concentrations is essential for the correct diagnosis and treatment management of children with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21 OHD). - Methods - We analysed 102 serum samples from 15 children with known 21 OHD twice using two different 17-OHP assays. 17-OHP concentrations were measured by an in-house radioimmunoassay (RIA) after recovery-corrected extraction and chromatographic purification and by a commercially available RIA without extraction (Immunotech). - Results - The correlation coefficient for results of pairs of 17-OHP concentrations was 0.974. The median ratio (17-OHP concentration measured with the commercial assay/17-OHP concentration measured with the in-house assay) was 0.593 with a 95% confidence interval ranging from 0.258 to 1.370. The ratio was constant throughout the average 17-OHP concentrations ranging from 0.24 to 149.2nmol/L, as well as throughout the age range from 0.3 to 16.4years. - Conclusions - Despite good overall correlation, absolute 17-OHP concentrations differed dramatically. This could lead to misclassification of patients suspected for 21 OHD on the basis of the hormonal profile and to a reduced quality during treatment monitoring of patients with 21 OHD with the risk of under- and overtreatment. |
DOI: | doi:10.1016/j.cca.2010.10.001 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cca.2010.10.001 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0009898110006315 |
| DOI: https://doi.org/10.1016/j.cca.2010.10.001 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 17-hydroxyprogesterone |
| 21-hydroxylase deficiency |
| Congenital adrenal hyperplasia |
| RIA |
K10plus-PPN: | 1809451906 |
Verknüpfungen: | → Zeitschrift |
Comparison of two different radioimmunoassays to measure 17-hydroxyprogesterone during treatment monitoring of children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency / Kamrath, Clemens [VerfasserIn]; 2011 (Online-Ressource)
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