Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Kamrath, Clemens [VerfasserIn]  |
| Maser-Gluth, Christiane [VerfasserIn]  |
| Haag, Christine [VerfasserIn]  |
| Schulze, Egbert [VerfasserIn]  |
Titel: | Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children |
Verf.angabe: | Clemens Kamrath, Christiane Maser-Gluth, Christine Haag, Egbert Schulze |
E-Jahr: | 2011 |
Jahr: | May 27, 2011 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 07.07.2022 |
Titel Quelle: | Enthalten in: Hormone research in paediatrics |
Ort Quelle: | Basel : Karger, 2010 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 76(2011), 2, Seite 93-98 |
ISSN Quelle: | 1663-2826 |
Abstract: | Objective: Glucocorticoid-remediable aldosteronism (GRA) is caused by the presence of a chimeric gene originating from an unequal cross-over between the CYP11B1 and CYP11B2 genes. Aldosterone suppression by dexamethasone and high 18-hydroxycortisol (18-OHF) levels have been used to differentiate GRA from the other forms of primary aldosteronism. Methods: A dexamethasone suppression test including serum 18-OHF determination and the measurement of urinary excretion of aldosterone, its metabolites and 18-OHF were performed in 3 children of a family with primary aldosteronism. Polymerase chain reactions were performed to identify the chimeric gene. Results: The chimeric gene was identified in 2 children, their mother and grandmother. The affected children had an aldosterone-to-plasma renin activity ratio >30, elevated serum 18-OHF concentration and increased urinary excretion of aldosterone, its metabolites, and 18-OHF. Post-dexamethasone concentrations of serum aldosterone and 18-OHF concentrations were suppressed. Conclusion: Although very rare, the possible diagnosis of GRA should be considered in all children or young adults with low-renin hypertension. Since genetic testing is more specific than biochemical testing, a definitive diagnosis can only be obtained by identification of the <i>CYP11B1/CYP11B2</i> chimeric gene. |
DOI: | doi:10.1159/000326524 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000326524 |
| Volltext: https://www.karger.com/Article/FullText/326524 |
| DOI: https://doi.org/10.1159/000326524 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1809452651 |
Verknüpfungen: | → Zeitschrift |
Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children / Kamrath, Clemens [VerfasserIn]; May 27, 2011 (Online-Ressource)
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