| Online-Ressource |
Verfasst von: | Sirmpilatze, Nikoloz [VerfasserIn]  |
| Mylius, Judith [VerfasserIn]  |
| Ortiz-Rios, Michael [VerfasserIn]  |
| Baudewig, Jürgen [VerfasserIn]  |
| Paasonen, Jaakko [VerfasserIn]  |
| Golkowski, Daniel [VerfasserIn]  |
| Ranft, Andreas [VerfasserIn]  |
| Ilg, Rüdiger [VerfasserIn]  |
| Gröhn, Olli [VerfasserIn]  |
| Boretius, Susann [VerfasserIn]  |
Titel: | Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents |
Verf.angabe: | Nikoloz Sirmpilatze, Judith Mylius, Michael Ortiz-Rios, Jürgen Baudewig, Jaakko Paasonen, Daniel Golkowski, Andreas Ranft, Rüdiger Ilg, Olli Gröhn, Susann Boretius |
E-Jahr: | 2022 |
Jahr: | May 24, 2022 |
Umfang: | 31 S. |
Fussnoten: | Gesehen am 08.07.2022 |
Titel Quelle: | Enthalten in: eLife |
Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 11(2022), Artikel-ID e74813, Seite 1-31 |
ISSN Quelle: | 2050-084X |
Abstract: | During deep anesthesia, the electroencephalographic (EEG) signal of the brain alternates between bursts of activity and periods of relative silence (suppressions). The origin of burst-suppression and its distribution across the brain remain matters of debate. In this work, we used functional magnetic resonance imaging (fMRI) to map the brain areas involved in anesthesia-induced burst-suppression across four mammalian species: humans, long-tailed macaques, common marmosets, and rats. At first, we determined the fMRI signatures of burst-suppression in human EEG-fMRI data. Applying this method to animal fMRI datasets, we found distinct burst-suppression signatures in all species. The burst-suppression maps revealed a marked inter-species difference: in rats, the entire neocortex engaged in burst-suppression, while in primates most sensory areas were excluded—predominantly the primary visual cortex. We anticipate that the identified species-specific fMRI signatures and whole-brain maps will guide future targeted studies investigating the cellular and molecular mechanisms of burst-suppression in unconscious states. |
DOI: | doi:10.7554/eLife.74813 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.74813 |
| DOI: https://doi.org/10.7554/eLife.74813 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | anesthesia |
| burst-suppression |
| common marmoset |
| fMRI |
| isoflurane |
| sevoflurane |
K10plus-PPN: | 1809470528 |
Verknüpfungen: | → Zeitschrift |
Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents / Sirmpilatze, Nikoloz [VerfasserIn]; May 24, 2022 (Online-Ressource)