| |  Online-Ressource |
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| Verfasst von: | Kulozik, Philipp [VerfasserIn]  |
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| | Jones, Allan [VerfasserIn] |
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| | Mattijssen, Frits [VerfasserIn] |
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| | Rose, Adam J. [VerfasserIn] |
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| | Reimann, Anja [VerfasserIn] |
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| | Strzoda, Daniela [VerfasserIn] |
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| | Kleinsorg, Stefan [VerfasserIn] |
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| | Raupp, Christina [VerfasserIn] |
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| | Kleinschmidt, Jürgen [VerfasserIn] |
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| | Müller-Decker, Karin [VerfasserIn] |
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| | Wahli, Walter [VerfasserIn] |
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| | Sticht, Carsten [VerfasserIn] |
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| | Gretz, Norbert [VerfasserIn] |
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| | von Loeffelholz, Christian [VerfasserIn] |
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| | Stockmann, Martin [VerfasserIn] |
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| | Pfeiffer, Andreas [VerfasserIn] |
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| | Stöhr, Sigrid [VerfasserIn] |
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| | Dallinga-Thie, Geesje M. [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Berriel Diaz, Mauricio [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| Titel: | Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia |
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| Verf.angabe: | Philipp Kulozik, Allan Jones, Frits Mattijssen, Adam J. Rose, Anja Reimann, Daniela Strzoda, Stefan Kleinsorg, Christina Raupp, Jürgen Kleinschmidt, Karin Müller-Decker, Walter Wahli, Carsten Sticht, Norbert Gretz, Christian von Loeffelholz, Martin Stockmann, Andreas Pfeiffer, Sigrid Stöhr, Geesje M. Dallinga-Thie, Peter P. Nawroth, Mauricio Berriel Diaz, and Stephan Herzig |
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| E-Jahr: | 2011 |
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| Jahr: | 5 April 2011 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 11.07.2022 |
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| Titel Quelle: | Enthalten in: Cell metabolism |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2005 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 13(2011), 4, Seite 389-400 |
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| ISSN Quelle: | 1932-7420 |
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| Abstract: | The aberrant accumulation of lipids in the liver (“fatty liver”) is tightly associated with several components of the metabolic syndrome, including type 2 diabetes, coronary heart disease, and atherosclerosis. Here we show that the impaired hepatic expression of transcriptional cofactor transducin beta-like (TBL) 1 represents a common feature of mono- and multigenic fatty liver mouse models. Indeed, the liver-specific ablation of TBL1 gene expression in healthy mice promoted hypertriglyceridemia and hepatic steatosis under both normal and high-fat dietary conditions. TBL1 deficiency resulted in inhibition of fatty acid oxidation due to impaired functional cooperation with its heterodimerization partner TBL-related (TBLR) 1 and the nuclear receptor peroxisome proliferator-activated receptor (PPAR) α. As TBL1 expression levels were found to also inversely correlate with liver fat content in human patients, the lack of hepatic TBL1/TBLR1 cofactor activity may represent a molecular rationale for hepatic steatosis in subjects with obesity and the metabolic syndrome. |
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| DOI: | doi:10.1016/j.cmet.2011.02.011 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cmet.2011.02.011 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1550413111000842 |
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| | DOI: https://doi.org/10.1016/j.cmet.2011.02.011 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1809699738 |
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| Verknüpfungen: | → Zeitschrift |
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Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia / Kulozik, Philipp [VerfasserIn]; 5 April 2011 (Online-Ressource)
