PLP-dependent enzymes as potential drug targets for protozoan diseases

• Verfasst von: Kappes, Barbara [VerfasserIn]
• Verfasst von: Tews, Ivo [VerfasserIn]
• Verfasst von: Binter, Alexandra [VerfasserIn]
• Verfasst von: Macheroux, Peter [VerfasserIn]
• Titel: PLP-dependent enzymes as potential drug targets for protozoan diseases
• Verf.angabe: Barbara Kappes, Ivo Tews, Alexandra Binter, Peter Macheroux
• E-Jahr: 2011
• Jahr: 24 July 2011
• Umfang: 10 S.
• Fussnoten: Gesehen am 11.07.2022
• Titel Quelle: Enthalten in: Biochimica et biophysica acta / Proteins and proteomics
• Ort Quelle: Amsterdam [u.a.], 2002
• Jahr Quelle: 2011
• Band/Heft Quelle: 1814(2011), 11, Seite 1567-1576
• ISSN Quelle: 1878-1454
• DOI: doi:10.1016/j.bbapap.2011.07.018
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antiprotozoan therapy
• Sach-SW: Aspartate transaminase
• Sach-SW: Cysteine desulfurase
• Sach-SW: Cysteine synthase
• Sach-SW: Ornithine decarboxylase
• Sach-SW: Serine hydroxymethyltransferase
• K10plus-PPN: 1809700574

Abstract

The chemical properties of the B6 vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B6 dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.